Bactericidal/permeability increasing protein and host defense against gram-negative bacteria and endotoxin.
Bactericidal/permeability increasing protein and host defense against gram-negative bacteria and endotoxin.
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DOI：
10.1016/0952-7915(93)90088-a
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发表时间：
1993-02
影响因子：
7
通讯作者：
P. Elsbach;Jerrold Weiss
中科院分区：
文献类型：
--
作者：
P. Elsbach;Jerrold Weiss
杀菌/通透性增加蛋白是宿主抵御革兰氏阴性细菌和内毒素的主要成分，作用于多形核白细胞的细胞内。作为一种分离的蛋白质，杀菌/通透性增加蛋白还可以作为细胞外杀菌和内毒素中和剂，当注射时，可以保护动物免受革兰氏阴性细菌和内毒素的致命影响。
The bactericidal/permeability increasing protein is a major element in the host defense against Gram-negative bacteria and endotoxin, acting intracellularly in the polymorphonuclear leukocyte. As an isolated protein, bactericidal/permeability increasing protein also acts as an extracellular bactericidal and endotoxin-neutralizing agent and, when injected, protects animals against lethal effects of Gram-negative bacteria and endotoxin.