Regional distribution of the histamine metabolite, tele-methylimidazoleacetic acid, in rat brain: effects of pargyline and probenecid.
Regional distribution of the histamine metabolite, tele-methylimidazoleacetic acid, in rat brain: effects of pargyline and probenecid.
复制标题
组胺代谢物远程甲基咪唑乙酸在大鼠脑中的区域分布：帕吉林和丙磺舒的作用。
DOI：
10.1111/j.1471-4159.1984.tb02708.x
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发表时间：
1984
影响因子：
4.7
通讯作者：
Green,JP
中科院分区：
文献类型：
--
作者：
Khandelwal,JK;Hough,LB;Green,JP
tele‐Methylimidazoleacetic acid (t‐MIAA), a major brain histamine metabolite, was measured in nine rat brain regions by a gas chromatography‐mass spectrometric method that also measures the precursor amine,tele‐methylhistamine (t‐MH). The t‐MIAA concentration of cerebellum, medulla‐pons, midbrain, caudate nucleus, hypothalamus, frontal cortex, hippocampus, and thalamus varied 15‐fold, hypothalamus showing the highest level (2.21 nmol/g) and cerebellum the lowest (0.15 nmol/ g). The concentrations of t‐MIAA and t‐MH were significantly correlated in all regions except midbrain, which had relatively more t‐MIAA. Probenecid did not alter whole‐brain t‐MIAA levels. Treatment with pargyline, an inhibitor of monoamine oxidase, lowered the t‐MIAA levels in all regions.
