Auditory brainstem response and unbound bilirubin in jaundiced (jj) Gunn rat pups
Auditory brainstem response and unbound bilirubin in jaundiced (jj) Gunn rat pups
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DOI：
10.1159/000047136
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发表时间：
2001-01-01
期刊：
影响因子：
--
通讯作者：
Shapiro, SM
中科院分区：
文献类型：
--
作者：
Ahlfors, CE;Shapiro, SM
血浆胆红素-白蛋白结合在新生儿核黄疸发病中的作用是有争议的。黄疸（jj） Gunn大鼠幼鼠核黄疸，听觉脑干反应（ABR）的波间间隔延长，波幅降低。测定16日龄jj Gunn大鼠（n = 21）的血浆总胆红素浓度（TBC）、白蛋白浓度和未结合胆红素浓度（UBC），并与ABR波潜伏期、波间间隔和波幅进行线性相关比较。UBC与ABR I-II和I-III间波间隔呈显著正相关（r = 0.55, p = 0.009, r = 0.60, p = 0.004），而TBC和TBC/白蛋白比值与ABR I-II和I-III间波间隔无显著正相关。UBC，而不是TBC或TBC/白蛋白比，预测胆红素毒性，通过胆红素诱导的ABR变化在jj Gunn大鼠幼崽中测量。版权所有(C) 2001 S. Karger AG，巴塞尔
The role of plasma bilirubin-albumin binding in the pathogenesis of kernicterus in human newborns is controversial. Kernicterus in the jaundiced (jj) Gunn rat pup, an animal model for kernicterus, prolongs interwave intervals and decreases wave amplitude in the auditory brainstem response (ABR). Plasma total bilirubin concentration (TBC), albumin concentration, and unbound bilirubin concentration (UBC), a measure of bilirubin-albumin binding, were measured in 16-day-old jj Gunn rat pups (n = 21) and compared with ABR wave latencies, interwave intervals, and wave amplitudes by linear correlation. The UBC, but not the TBC or TBC/albumin ratio, correlated positively and significantly with ABR I-II and I-III interwave intervals (r = 0.55, p = 0.009, and r = 0.60, p = 0.004, respectively). The UBC, but not the TBC or TBC/albumin ratio, predicts bilirubin toxicity, as measured by bilirubin-induced ABR changes in jj Gunn rat pups. Copyright (C) 2001 S. Karger AG, Basel.