Caffeic acid attenuates the decrease in cortical BDNF mRNA expression induced by exposure to forced swimming stress in mice.
Caffeic acid attenuates the decrease in cortical BDNF mRNA expression induced by exposure to forced swimming stress in mice.
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DOI：
10.1016/j.ejphar.2006.01.026
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发表时间：
2006-03
影响因子：
5
通讯作者：
H. Takeda;M. Tsuji;Tomoko Yamada;Jiro Masuya;K. Matsushita;Masashi Tahara;M. Iimori;T. Matsumiya
中科院分区：
文献类型：
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作者：
H. Takeda;M. Tsuji;Tomoko Yamada;Jiro Masuya;K. Matsushita;Masashi Tahara;M. Iimori;T. Matsumiya
我们之前报道过咖啡酸在小鼠（一种抑郁症动物模型）的强迫游泳试验中产生类似抗抑郁的作用。越来越多的证据表明，脑源性神经营养因子（BDNF）是神经营养因子家族的一员，对酪氨酸激酶受体B （TrkB）具有高亲和力，在抑郁症的病理生理和治疗中发挥重要作用。本研究检测了咖啡酸是否影响强迫游泳小鼠脑区BDNF和TrkB mRNA的表达水平。咖啡酸（4mg/kg, i.p.）减少小鼠在强迫游泳试验中的静止时间。强迫游泳实验后，大鼠额叶皮质BDNF mRNA和杏仁核TrkB mRNA水平显著降低，咖啡酸（4mg/kg, i.p）显著抑制前者的降低。咖啡酸（4mg/kg, i.p）没有改变幼稚小鼠脑区BDNF和TrkB mRNA的水平。这些结果表明，咖啡酸可以减弱应激条件下BDNF转录的下调。
We previously reported that caffeic acid produces antidepressive-like effects in the forced swimming test in mice, an animal model of depression. Increased evidence suggests that brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family that has high affinity for the tyrosine kinase receptor B (TrkB), plays an important role in the pathophysiology and treatment of depression. The present study examined whether caffeic acid affects the expression levels of BDNF and TrkB mRNA in brain regions of mice subjected to a forced swimming test. Caffeic acid (4mg/kg, i.p.) reduced the duration of immobility of mice in the forced swimming test. The levels of BDNF mRNA in the frontal cortex as well as TrkB mRNA in the amygdala were significantly decreased after the forced swimming test, and the former reduction was significantly inhibited by caffeic acid (4mg/kg, i.p.). Caffeic acid (4mg/kg, i.p.) did not modify the levels of BDNF and TrkB mRNA in brain regions of naive mice. These results suggest that caffeic acid can attenuate the down-regulation of BDNF transcription that results from stressful conditions.