Epigallocatechin-3-gallate increases maximal oxygen uptake in adult humans.
Epigallocatechin-3-gallate increases maximal oxygen uptake in adult humans.
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DOI：
10.1249/mss.0b013e3181bcab6c
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发表时间：
2010-04
影响因子：
4.1
通讯作者：
Bell C
中科院分区：
文献类型：
--
作者：
Richards JC;Lonac MC;Johnson TK;Schweder MM;Bell C
表没食子儿茶素-3-没食子酸酯（EGCG）是绿茶的一种成分，可以提高动物的耐力，并在成年人的循环运动中促进脂肪氧化。我们研究了短期消耗EGCG延迟通气阈值（TVE）的发生和增加最大摄氧量（VO2max）的假设。在这项随机、重复测量、双盲研究中，19名健康成年人（11名男性，8名女性，年龄：26±2岁（平均±SE））服用7粒安慰剂或7粒EGCG （135 mg）药片。数据收集前48小时，参与者开始每天服用3片；最后一片药丸在运动试验前2小时服用。TVE和VO2max是根据从休息到意志疲劳的连续增量固定循环运动（20-35 W/min）中收集的逐呼吸间接量热数据来测定的。每次状态/运动试验至少间隔14天。与安慰剂组相比，短期摄入EGCG组VO2max增加（3.123±0.187 vs. 3.259±0.196 L·min-1， P=0.04）。最大工作速率（301±15 vs 301±16 W， P=0.98）、最大呼吸交换比（1.21±0.01 vs 1.22±0.02，P=0.27）和最大心率（180±3 vs 180±3次·min-1， P=0.87）不受影响。在一部分受试者（n=11）中，最大心输出量（通过开路乙炔呼吸测定）也不受EGCG的影响（29.6±2.2 vs. 30.2±1.4 L·min-1， P=0.70）。与我们的假设相反，EGCG在TVE时降低了VO2(1.57±0.11 vs. 1.48±0.10 L·min-1)，但这种变化并不显著（P=0.06）。短期摄入EGCG可增加VO2max，但不影响最大心输出量，提示EGCG可能增加动静脉氧差。
Epigallocatechin-3-gallate (EGCG), a component of green tea, increases endurance performance in animals and promotes fat oxidation during cycle ergometer exercise in adult humans. We have investigated the hypothesis that short-term consumption of EGCG delays the onset of the ventilatory threshold (TVE) and increases maximal oxygen uptake (VO2max). In this randomized, repeated measures, double blind study, 19 healthy adults (11 males, 8 females, age: 26 ± 2 years (mean ± SE)) received 7 placebo or 7 EGCG (135 mg) pills. 48-hours prior to data collection participants began consuming 3 pills per day; the last pill was taken 2-hours before exercise testing. TVE and VO2max were determined from breath-by-breath indirect calorimetry data collected during continuous incremental stationary cycle ergometer exercise (20-35 W/min), from rest until volitional fatigue. Each condition/exercise test was separated by a minimum of 14-days. Compared with placebo, short-term EGCG consumption increased VO2max (3.123 ± 0.187 vs. 3.259 ± 0.196 L·min-1, P=0.04). Maximal work rate (301 ± 15 vs. 301 ± 16 W, P=0.98), maximal respiratory exchange ratio (1.21 ± 0.01 vs. 1.22 ± 0.02, P=0.27), and maximal heart rate were unaffected (180 ± 3 vs. 180 ± 3 beats·min-1, P=0.87). In a subset of subjects (n=11) maximal cardiac output (determined via open-circuit acetylene breathing) was also unaffected by EGCG (29.6 ± 2.2 vs. 30.2 ± 1.4 L·min-1, P=0.70). Contrary to our hypothesis, EGCG decreased VO2 at TVE (1.57 ± 0.11 vs. 1.48 ± 0.10 L·min-1) but this change was not significant (P=0.06). Short-term consumption of EGCG increased VO2max without affecting maximal cardiac output, suggesting that EGCG may increase arterial-venous oxygen difference.