The changes in quality of mandibular bone mineral in otherwise totally immobilized rhesus monkeys.
The changes in quality of mandibular bone mineral in otherwise totally immobilized rhesus monkeys.
复制标题
完全固定的恒河猴下颌骨矿物质质量的变化。
DOI：
10.1007/bf02553291
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发表时间：
1986
影响因子：
4.2
通讯作者：
Simmons,DJ
中科院分区：
文献类型：
--
作者：
Grynpas,MD;Patterson-Allen,P;Simmons,DJ
在年轻的成年恒河猴下颌骨骨骨矿物质和骨钙素的状态进行了评估后，14天的颅后制动期，并在7天和28天的恢复期。从颌骨下缘的密质骨中取出皮质骨样本，在液氮中研磨并筛分至20 μm以下的特定尺寸。然后将骨粉在溴甲烷-甲苯密度梯度中分级，以确定其矿化概况（Ca、P、CO 3和骨钙素），并使用X射线衍射来确定某些馏分中的磷灰石晶体尺寸。固定动物下颌骨的化学成分没有变化。然而，该组的矿化曲线显示出向较高密度部分的显著转变，表明存在大于正常含量的成熟矿化良好的骨。虽然在7天的制动后恢复期后，这种趋势在颌骨中加重，但在28天的恢复期后观察到正常轮廓的部分恢复。在制动和恢复期间，骨钙素曲线像矿化曲线一样发生变化。X-射线衍射分析表明，矿化曲线在固定期间的转变与磷灰石晶体尺寸的减少有关。
The status of bone mineral and osteocalcin in the young adult Rhesus monkey mandible was assessed following a 14-day period of postcranial immobilization, and after 7- and 28-day recovery periods. Specimens of cortical bone taken from the compact bone at the inferior border of the jaws were ground in liquid nitrogen and sieved to a particular size below 20 μm. The bone powder was then fractionated in a bromoform-toluene density gradient to determine its mineralization profile (Ca, P, CO3, and osteocalcin), and X-ray diffraction was used to determine apatite crystal size in some fractions. There was no change in the chemistry of the mandibular bone from the immobilized animals. However, the mineralization profile in that group showed a significant shift toward the higher density fractions, indicating the presence of a greater than normal content of mature well-mineralized bone. While this trend was accentuated in the jaws following a 7-day postimmobilization recovery period, partial recovery of the normal profile was observed after a 28-day recovery period. The osteocalcin profile shifted like the mineralization profile during the immobilization and recovery periods. X-ray diffraction analyses showed that the shift in the mineralization profile during the immobilization period was associated with a decrease in apatite crystal size.