Chiral Acid-Catalyzed AsymmetricNazarov Reaction: Nucleophilic Construction of a QuaternaryAsymmetric Center at the α-Position of the KetoFunction
Chiral Acid-Catalyzed AsymmetricNazarov Reaction: Nucleophilic Construction of a QuaternaryAsymmetric Center at the α-Position of the KetoFunction
复制标题
手性酸催化的不对称纳扎罗夫反应：酮基函数 α 位的四元不对称中心的亲核构建
DOI：
10.1055/s-0029-1217823
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
M. Shindo
中科院分区：
文献类型：
--
作者：
K. Yaji;M. Shindo
研究了手性刘易斯酸催化的Nazarov反应合成α-烷氧基环戊烯酮的反应条件。这是第一个使用单齿配位的二乙烯基酮通过中断的Nazarov反应构建不对称季中心的例子，该反应涉及醇对酮官能团的α-位的亲核攻击。
A chiral Lewis acid catalyzed enantioselective Nazarov reaction affording α-alkoxy cyclopentenones has been developed. This is the first example for construction of an asymmetric quaternary center by using the monodentate coordinated divinyl ketones via the interrupted Nazarov reaction, which involves a nucleophilic attack of an alcohol on the α-position of the keto function.