A Pilot Study on the Urinary Excretion of Porphyrins in Human Populations Chronically Exposed to Arsenic in Mexico
A Pilot Study on the Urinary Excretion of Porphyrins in Human Populations Chronically Exposed to Arsenic in Mexico
复制标题
墨西哥长期暴露于砷的人群中卟啉尿排泄的初步研究
DOI：
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发表时间：
1991
影响因子：
2.8
通讯作者：
M. Cebrián
中科院分区：
文献类型：
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作者：
G. Garcia;Adalberto García;Manuel Aguilar;J. García‐Salcedo;L. D. Del Razo;P. Ostrosky;Cristina Cortinas de Nava;M. Cebrián
1本初步研究的目的是调查在啮齿动物中由砷产生的卟啉尿症是否存在于通过饮用水长期暴露于砷的人类中。2比较了21名饮水砷暴露者（0.390mg1 ~（-1））和19名对照者（0.012mg1 ~（-1））尿卟啉、粪卟啉和尿总砷的浓度。3砷暴露者尿中总砷浓度显著高于对照组。暴露者的尿卟啉排泄量没有增加。然而，在大多数接触者中观察到粪卟啉/尿卟啉（COPRO/ URO）比值倒置。这种倒置是由粪卟啉排泄减少和尿卟啉排泄增加引起的。4卟啉排泄量、COPRO/URO比值与尿总砷浓度之间无明显相关性。
1 The aim of this pilot study was to investigate if the porphyrinuria produced by arsenic in rodents was present in humans chronically exposed to arsenic via drinking water. 2 The concentrations of uroporphyrin, coproporphyrin and total arsenic in urine were compared between 21 individuals exposed to arsenic in their drinking water (0.390 mg 1-1) and 19 controls exposed to 0.012 mg 1-1. 3 Arsenic-exposed individuals had significantly higher total arsenic concentrations in their urine than the control group. No increase in urinary porphyrin excretion was found in exposed individuals. However, an inversion of the coproporphyrin/uroporphyrin (COPRO/ URO) ratio was observed in most exposed individuals. This inversion was caused both, by a decrease in coproporphyrin excretion and an increase in uroporphyrin excretion. 4 No demonstrable correlations between porphyrin excretion, the COPRO/URO ratio and total arsenic concentration in urine were found in exposed individuals.