Wave number-spiral acoustic tweezers for dynamic and reconfigurable manipulation of particles and cells
Wave number-spiral acoustic tweezers for dynamic and reconfigurable manipulation of particles and cells
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DOI：
10.1126/sciadv.aau6062
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发表时间：
2019-05-01
期刊：
影响因子：
13.6
通讯作者：
Huang, Tony Jun
中科院分区：
文献类型：
--
作者：
Tian, Zhenhua;Yang, Shujie;Huang, Tony Jun
近年来，声镊因其无接触、无标记、生物相容性好、能精确操纵细胞和粒子等优点，引起了生物、化学、工程和医学等领域的广泛关注。在这里，我们提出了波数螺旋声镊，这是能够动态重塑表面声波（SAW）波场的各种压力分布，以促进动态和可编程的粒子/细胞操纵。通过简单地调制多频激励信号，可以同时独立地控制多个方向上的声表面波传播。这允许将SAW波场动态重塑为期望的分布，从而实现可编程的粒子/细胞操纵。我们通过实验证明了波数螺旋声镊的多种功能，其中包括多配置图案化;平行合并;图案平移，变换和旋转;以及单微粒沿着复杂路径的动态平移。这种波数螺旋设计有可能彻底改变未来的声镊发展，并推动许多应用，包括微尺度组装，生物打印和细胞间相互作用研究。
Acoustic tweezers have recently raised great interest acrossmany fields including biology, chemistry, engineering, and medicine, as they can perform contactless, label-free, biocompatible, and precise manipulation of particles and cells. Here, we present wave number-spiral acoustic tweezers, which are capable of dynamically reshaping surface acoustic wave (SAW) wavefields to various pressure distributions to facilitate dynamic and programmable particle/cell manipulation. SAWs propagating inmultiple directions can be simultaneously and independently controlled by simplymodulating the multitone excitation signals. This allows for dynamic reshaping of SAWwavefields to desired distributions, thus achieving programmable particle/cell manipulation. We experimentally demonstrated the multiple functions of wave number-spiral acoustic tweezers, among which are multiconfiguration patterning; parallel merging; pattern translation, transformation, and rotation; and dynamic translation of single microparticles along complex paths. This wave number-spiral design has the potential to revolutionize future acoustic tweezers development and advance many applications, including microscale assembly, bioprinting, and cell-cell interaction research.