Selective reduction of diffusion anisotropy in white matter of Alzheimer disease brains measured by 3.0 Tesla magnetic resonance imaging
Selective reduction of diffusion anisotropy in white matter of Alzheimer disease brains measured by 3.0 Tesla magnetic resonance imaging
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DOI：
10.1016/s0304-3940(02)00914-x
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发表时间：
2002-10-25
影响因子：
2.5
通讯作者：
Tohgi, H
中科院分区：
文献类型：
--
作者：
Takahashi, S;Yonezawa, H;Tohgi, H
阿尔茨海默病（Alzheimer disease，AD）是一种以脑皮质萎缩为主要病理特征的疾病。白色物质的变化及其与AD发病机制的关系仍有待研究。为了定量研究AD患者白色物质纤维束的完整性和组织结构，我们使用扩散张量（DT）成像来研究白色物质区域的扩散各向异性。使用3.0特斯拉磁共振扫描仪对10名可能的AD患者进行DT成像，T2加权磁共振成像中白色物质没有或只有轻微变化，并对10名组匹配的对照组进行检查。与对照组相比，AD患者颞叶皮质下白色物质、胼胝体后部和前后扣带回束的分数各向异性值显著降低。对这些白色物质的选择性损害与大脑后叶皮质和海马的病理变化的可能关系进行了讨论。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Alzheimer disease (AD) is pathologically characterized by cortical atrophy. Changes in the white matter and their relation to the pathogenesis of AD remain to be studied. To quantitatively investigate the integrity and organization of white matter fiber tracts in patients with AD,we used diffusion tensor(DT) imaging to study the diffusion anisotropy of white matter regions. DT imaging was performed using a 3.0 Tesla magnetic resonance scanner in ten probable AD patients with no or only mild changes in the white matter in T2 weighted magnetic resonance imagings and ten group-matched controls. The values of fractional anisotropy were significantly lower in the temporal subcortical white matter, posterior part of the corpus callosum, and anterior and posterior cingulate bundles in patients with AD compared with controls. Possible relationships of these selective impairments in the white matter with pathological changes in the poterior cerebral cortices and hippocampus were discussed. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.