Dietary canola oil suppressed growth of implanted MDA-MB 231 human breast tumors in nude mice
Dietary canola oil suppressed growth of implanted MDA-MB 231 human breast tumors in nude mice
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DOI：
10.1080/01635580701277445
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发表时间：
2007-01-01
影响因子：
2.9
通讯作者：
Hardman, W. Elaine
中科院分区：
文献类型：
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作者：
Hardman, W. Elaine
长链ω -3 （n-3）脂肪酸，二十碳五烯酸（EPA）和/或二十二碳六烯酸（DHA），已被证明可以抑制大多数癌细胞的生长。体内α -亚麻酸（ALA, 18:3n-3）可转化为EPA或DHA。我们假设用菜籽油（10% ALA）代替患癌小鼠饮食中的玉米油（1% ALA）可以通过增加饮食中的n-3脂肪酸来减缓肿瘤的生长。60只裸鼠接受MDA-MB 231人乳腺癌细胞，饲喂含有8% w/w玉米油的日粮，直到肿瘤平均体积为60 mm 3。然后将一半荷瘤小鼠的膳食脂肪改为8% w/w的菜籽油。与玉米油组相比，菜籽油组小鼠肿瘤和肝脏中EPA和DHA含量显著增加，平均肿瘤生长速度和肿瘤细胞增殖速度显著减慢（P < 0.05）。饮食改变后大约25天，食用玉米油饮食的老鼠体重停止增加，而食用菜籽油饮食的老鼠体重继续正常增加。在饮食中使用菜籽油代替玉米油可能是增加n-3脂肪酸摄入的一种合理手段，对减缓癌症幸存者体内残留癌细胞的生长具有潜在意义。
Long chain omega 3 (n-3)fatty acids, eicosapentaenoic (EPA) and/or docosahexaenoic acid (DHA), have been shown to suppress growth of most cancer cells. In vivo, alpha linolenic acid (ALA, 18:3n-3) can be converted to EPA or DHA. We hypothesized that substituting canola oil (10% ALA)for the corn oil (1% ALA) in the diet of cancer bearing mice would slow tumor growth by increasing n-3 fatty acids in the diet. Sixty nude mice received MDA-MB 231 human breast cancer cells and were fed a diet containing 8% w/w corn oil oil until the mean tumor volume was 60 mm 3. The dietary fat of half of the tumor bearing mice was then changed to 8% w/w canola oil. Compared to mice that consumed the corn oil containing diet, the mice that consumed the canola oil containing diet had significantly more EPA and DHA in both tumors and livers, and the mean tumor growth rate and cell proliferation in the tumor were significantly slower (P < 0.05). About 25 days after diet change, mice that consumed the corn oil diet stopped gaining weight, whereas the mice that consumed the canola oil diet continued normal weight gain. Use of canola oil instead of corn oil in the diet may be a reasonable means to increase consumption of n-3 fatty acids with potential significance for slowing growth residual cancer cells in cancer survivors.