Effects of Qianliening capsule on the expression of IL-10 and TNF-α in benign prostatic hyperplasia
Effects of Qianliening capsule on the expression of IL-10 and TNF-α in benign prostatic hyperplasia
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发表时间：
2010
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通讯作者：
Hong Zhen-feng
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作者：
Hong Zhen-feng
目的：研究前连宁胶囊（QLNC）对睾丸激素诱导的良性前列腺增生（BPH）大鼠去势后白细胞介素-10（IL-10）和肿瘤坏死因子-α(TNF-α)表达的影响。方法：将60只大鼠随机分为6组：1组为正常组；第二组为模型组；第3组为阳性对照组，给予非那雄胺0.5 mg·kg-1·d-1g；4 ~ 6组分别给予2.25g·kg-1·d-1、4.5g·kg-1·d-1、9g·kg-1·d-1剂量的QLNC；每天口服给药，连续28天。检测大鼠前列腺重量、体积、前列腺指数、组织病理学变化及前列腺组织中IL-10、TNF-α的表达。结果：去势后大鼠前列腺重量、体积、前列腺指数及睾酮所致组织病理学改变均明显降低。RT-PCR检测显示，QLNC治疗后前列腺组织中IL-10表达升高，TNF-α表达抑制。结论：QLNC对BPH有明显抑制作用，是其通过抑制炎症因子治疗BPH的重要机制之一。
Objective:The purpose of this study was to study the expression of Qianliening capsule(QLNC) on interleukin-10(IL-10) and tumor necrosis factor-α(TNF-α) in benign prostatic hyperplasia(BPH) in rats induced by testosterone after castration.Methods:A total of 60 rats were equally divided into six groups: Group 1 was normal group;Group 2 was model group;Group 3 served as positive control group and treated with finasteride at a dose of 0.5 mg·kg-1·d-1g.;Group 4 to Group 6 animals were administered with QLNC at dose levels of 2.25g·kg-1·d-1 and 4.5g·kg-1·d-1 and 9g·kg-1·d-1;The drugs were administered orally each day for 28 days consecutively.The prostate weight,volume,prostatic index,histopathological changes and the expressions of IL-10 and TNF-α in prostate were examinated.Results:The prostate weight,volume,prostatic index,the histopathological changes induced by testosterone after castration were significantly reduced.RT-PCR examination revealed that the expressions of IL-10 were increased and TNF-α in prostate were inhibited by QLNC treatment.Conclusion: QLNC can inhibit BPH significantly,It is one of important mechanism in treating BPH through inhibiting inflammatory factors.