HIV accessory proteins and surviving the host cell.
HIV accessory proteins and surviving the host cell.
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DOI：
10.1007/s11904-004-0007-x
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发表时间：
2004-04-01
影响因子：
4.6
通讯作者：
Hope, Thomas J
中科院分区：
文献类型：
--
作者：
Anderson, Jenny L;Hope, Thomas J
人类免疫缺陷病毒在宿主细胞中病毒复制期间产生辅助蛋白Nef、病毒感染因子（Vif）、病毒蛋白R和病毒蛋白U或病毒蛋白X。虽然这些辅助蛋白的重要性往往在体外丢失，但它们对体内病毒致病是必需的。因此，这些蛋白具有作为抗病毒靶点的潜力。最近的数据显示，Vif扰乱了宿主细胞中一个不明确的抗病毒途径，使HIV得以复制。这些数据突出了HIV辅助蛋白在操纵宿主以帮助病毒致病方面的共同特征。因此，这些新的见解Vif和其他艾滋病毒辅助蛋白进行审查，强调宿主细胞的相互作用和新的治疗干预的目标。
Human immunodeficiency virus generates the accessory proteins Nef, viral infectivity factor (Vif), viral protein R, and viral protein U or viral protein X during viral replication in host cells. Although the significance of these accessory proteins is often lost in vitro, they are essential for viral pathogenesis in vivo. Therefore, these proteins have much potential as antiviral targets. Recent data reveal Vif perturbs an ill-defined antiviral pathway in host cells allowing HIV replication. These data highlight a common feature among HIV accessory proteins in manipulating the host to aid viral pathogenesis. Therefore, these new insights into Vif and other HIV accessory proteins are reviewed, emphasizing host cell interactions and new targets for therapeutic intervention.