Endoplasmic reticulum-mediated protein quality control in Arabidopsis.
Endoplasmic reticulum-mediated protein quality control in Arabidopsis.
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DOI：
10.3389/fpls.2014.00162
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发表时间：
2014
影响因子：
5.6
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Liu Y;Li J
正确的三维结构对于蛋白质的生理功能至关重要，但蛋白质折叠以获得天然构象从根本上来说是一个容易出错的过程。真核生物已经进化出高度保守的内质网介导的蛋白质质量控制（ERQC）机制来监测分泌蛋白和膜蛋白的折叠过程，允许仅将正确折叠的蛋白质输出到其生理目的地，将不完全/错误折叠的蛋白质保留在ER中以进行额外的折叠尝试，通过独特的方法标记和去除最终错误折叠的蛋白质。 多步降解过程称为 ER 相关降解 (ERAD)。我们目前关于 ERQC 和 ERAD 的大部分知识都来自对酵母和哺乳动物细胞的遗传和生化研究。最近对参考植物拟南芥的研究发现了植物中用于监测蛋白质折叠以及保留、修复和去除错误折叠蛋白质的同源成分和相似机制。这些研究还揭示了植物 ERQC/ERAD 系统在调节重要生化/生理过程（例如非生物胁迫耐受性和植物防御）中的关键作用。在这篇综述中，我们与酵母和哺乳动物系统相比，讨论了我们目前对植物 ERQC/ERAD 系统的分子成分和生化机制的理解。
A correct three-dimensional structure is crucial for the physiological functions of a protein, yet the folding of proteins to acquire native conformation is a fundamentally error-prone process. Eukaryotic organisms have evolved a highly conserved endoplasmic reticulum-mediated protein quality control (ERQC) mechanism to monitor folding processes of secretory and membrane proteins, allowing export of only correctly folded proteins to their physiological destinations, retaining incompletely/mis-folded ones in the ER for additional folding attempts, marking and removing terminally misfolded ones via a unique multiple-step degradation process known as ER-associated degradation (ERAD). Most of our current knowledge on ERQC and ERAD came from genetic and biochemical investigations in yeast and mammalian cells. Recent studies in the reference plant Arabidopsis thaliana uncovered homologous components and similar mechanisms in plants for monitoring protein folding and for retaining, repairing, and removing misfolded proteins. These studies also revealed critical roles of the plant ERQC/ERAD systems in regulating important biochemical/physiological processes, such as abiotic stress tolerance and plant defense. In this review, we discuss our current understanding about the molecular components and biochemical mechanisms of the plant ERQC/ERAD system in comparison to yeast and mammalian systems.
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DOI：
10.1016/j.bbamcr.2013.03.007
发表时间：
2013-11
影响因子：
5.1
作者：
Gidalevitz, Tali;Stevens, Fred;Argon, Yair
通讯作者：
Argon, Yair
影响因子：
7.2
作者：
Brandizzi, F;Hanton, S;Hawes, C
通讯作者：
Hawes, C
影响因子：
7.2
作者：
Diepold, Andreas;Li, Guangtao;Brunner, Frederic
通讯作者：
Brunner, Frederic
影响因子：
16
作者：
Bagola, Katrin;von Delbrueck, Maximilian;Sommer, Thomas
通讯作者：
Sommer, Thomas
影响因子：
4.1
作者：
Galvao, Rafaelo M.;Kota, Uma;Boss, Wendy F.
通讯作者：
Boss, Wendy F.