Controllable preparation of graphene oxide/metal nanoparticle hybrids as surface-enhanced Raman scattering substrates for 6-mercaptopurine detection
Controllable preparation of graphene oxide/metal nanoparticle hybrids as surface-enhanced Raman scattering substrates for 6-mercaptopurine detection
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DOI：
10.1039/c4ra00658e
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发表时间：
2014-03
期刊：
影响因子：
3.9
通讯作者：
W. Fu;S. Zhen;C. Huang
中科院分区：
文献类型：
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作者：
W. Fu;S. Zhen;C. Huang
在这项研究中，报道了一种通过聚乙烯亚胺（PEI）分子介导制备氧化石墨烯（GO）和金属纳米粒子（MNPs）杂化物的新的简单且具有成本效益的策略。作为阳离子聚合物的PEI分子能够有效地附着在GO表面，以便进一步吸附带负电的MNP。通过这一过程，金和银纳米粒子高效地组装在GO上。该方法也已成功应用于金属纳米粒子和碳纳米管（CNTs）的组装，表明这种方法具有普遍性。此外，所制备的氧化石墨烯/银纳米粒子（GO/AgNP）杂化物已被用作理想的表面增强拉曼散射（SERS）基底，增强因子为1.5×10⁵，并成功应用于药物片剂中6 - 巯基嘌呤（6MP）的灵敏和选择性检测，结果令人满意。
In this contribution, a new simple and cost-effective strategy for the preparation of hybrids of graphene oxide (GO) and metal nanoparticles (MNPs) through the mediation of polyethyleneimine (PEI) molecules was reported. PEI molecules as cationic polymers could effectively attach onto the surface of GO for further negative MNP adsorption. By this process, gold and silver nanoparticles are assembled on GO with high efficiency. This method has also been successfully applied to the assembly of metal nanoparticles and carbon nanotubes (CNTs), indicating that this method is general. Furthermore, the as-prepared graphene oxide/silver nanoparticle (GO/AgNP) hybrids have been used as perfect surface enhanced Raman scattering (SERS) substrates with an enhancement factor of 1.5 × 105 and successfully applied for the sensitive and selective detection of 6-mercaptopurine (6MP) in pharmaceutical tablets with satisfactory results.