Opioid Receptors and Their Ligands
Opioid Receptors and Their Ligands
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DOI：
10.1007/978-1-4612-3514-9_20
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
L. Terenius
中科院分区：
文献类型：
--
作者：
L. Terenius
在过去的十年中，阿片受体一直是积极研究工作的焦点。从最初的概念，一个药理学受体互补吗啡样剂，一个更复杂的图片已经出现。已经鉴定了与阿片类药物相互作用的受体家族，统称为阿片受体。对这些受体的兴趣不仅源于药理学的理由，而且还源于需要表征其内源性配体，阿片肽或内啡肽的生理重要性。本章将讨论后一个方面。
Opioid receptors have been the focus of vigorous research efforts during the past decade. From the initial concept of a pharmacologic receptor complementary to morphine-like agents, a much more complex picture has emerged. A family of receptors, collectively known as opioid receptors, which interact with opioids, has been identified. The interest in these receptors stems not only from pharmacologic grounds but also from the need to characterize the physiologic importance of their endogenous ligands, the opioid peptides or endorphins. This latter aspect will be considered in the present chapter.