Mechanisms of Macrophage Plasticity in the Tumor Environment: Manipulating Activation State to Improve Outcomes.
Mechanisms of Macrophage Plasticity in the Tumor Environment: Manipulating Activation State to Improve Outcomes.
复制标题
肿瘤环境中巨噬细胞可塑性的机制：操纵激活状态以改善结果。
DOI：
10.3389/fimmu.2021.642285
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发表时间：
2021
影响因子：
7.3
通讯作者：
Ubil E
中科院分区：
文献类型：
--
作者：
Ricketts TD;Prieto-Dominguez N;Gowda PS;Ubil E
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Macrophages are a specialized class of innate immune cells with multifaceted roles in modulation of the inflammatory response, homeostasis, and wound healing. While developmentally derived or originating from circulating monocytes, naïve macrophages can adopt a spectrum of context-dependent activation states ranging from pro-inflammatory (classically activated, M1) to pro-wound healing (alternatively activated, M2). Tumors are known to exploit macrophage polarization states to foster a tumor-permissive milieu, particularly by skewing macrophages toward a pro-tumor (M2) phenotype. These pro-tumoral macrophages can support cancer progression by several mechanisms including immune suppression, growth factor production, promotion of angiogenesis and tissue remodeling. By preventing the adoption of this pro-tumor phenotype or reprogramming these macrophages to a more pro-inflammatory state, it may be possible to inhibit tumor growth. Here, we describe types of tumor-derived signaling that facilitate macrophage reprogramming, including paracrine signaling and activation of innate immune checkpoints. We also describe intervention strategies targeting macrophage plasticity to limit disease progression and address their implications in cancer chemo- and immunotherapy.
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影响因子：
6.5
作者：
Bensinger, William;Maziarz, Richard T.;Stadtmauer, Edward A.
通讯作者：
Stadtmauer, Edward A.
影响因子：
5.6
作者：
Amano, Mariane T.;Castoldi, Angela;Camara, Niels O. S.
通讯作者：
Camara, Niels O. S.
影响因子：
6.7
作者：
Ait-Lounis, Aouatef;Laraba-Djebari, Fatima
通讯作者：
Laraba-Djebari, Fatima
影响因子：
8.7
作者：
Allard B;Longhi MS;Robson SC;Stagg J
通讯作者：
Stagg J
影响因子：
64.5
作者：
Azizi E;Carr AJ;Plitas G;Cornish AE;Konopacki C;Prabhakaran S;Nainys J;Wu K;Kiseliovas V;Setty M;Choi K;Fromme RM;Dao P;McKenney PT;Wasti RC;Kadaveru K;Mazutis L;Rudensky AY;Pe'er D
通讯作者：
Pe'er D