TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons.
TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons.
复制标题
TGF beta 2 和 TGF beta 3 是中脑多巴胺能神经元的有效生存因子。
作者：
K. Poulsen;M. Armanini;R. D. Klein;M. Hynes;H. Phillips;A. Rosenthal
脊椎动物腹侧中脑含有3-4 × 10（4）多巴胺能神经元，影响运动活动、情绪行为和认知。最近，胶质细胞源性神经营养因子（GDNF）被证明是这些多巴胺能神经元在培养中的一个有效的生存因子。然而，许多中脑多巴胺能神经元投射到不表达GDNF的靶点。我们在这里报告，转化生长因子（TGF）TGF β 2和TGF β 3，这是遥远的GDNF，也防止死亡的培养大鼠胚胎中脑多巴胺能神经元在皮摩尔浓度。此外，我们发现，TGF β 2，TGF β 3，和GDNF表达顺序作为本地和目标衍生的营养因子和亚群的多巴胺能神经元投射到不同的目标只有这些因素之一。这些发现与GDNF、TGF β 2和TGF β 3是发育中脑多巴胺能神经元的生理存活因子的想法一致，并且可能具有作为帕金森病（多巴胺能神经元的神经退行性疾病）的治疗剂的应用。
The vertebrate ventral midbrain contains 3-4 x 10(4) dopaminergic neurons that influence motor activity, emotional behavior, and cognition. Recently, glial cell line-derived neurotrophic factor (GDNF) was shown to be a potent survival factor for these dopaminergic neurons in culture. However, many midbrain dopaminergic neurons project to targets that do not express GDNF. We report here that transforming growth factors (TGFs) TGF beta 2 and TGF beta 3, which are distantly related to GDNF, also prevent the death of cultured rat embryonic midbrain dopaminergic neurons at picomolar concentrations. Furthermore, we find that TGF beta 2, TGF beta 3, and GDNF are expressed sequentially as local and target-derived trophic factors and that subpopulations of dopaminergic neurons projecting to distinct targets have access to only one of these factors. These findings are consistent with the idea that GDNF, TGF beta 2, and TGF beta 3 are physiological survival factors for developing midbrain dopaminergic neurons and may have applications as therapeutics for Parkinson's disease, a neurodegenerative disorder of dopaminergic neurons.