Association of serum phosphate levels with aortic valve sclerosis and annular calcification: the cardiovascular health study.
Association of serum phosphate levels with aortic valve sclerosis and annular calcification: the cardiovascular health study.
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血清磷酸盐水平与主动脉瓣硬化和环形钙化的关联：心血管健康研究。
DOI：
10.1016/j.jacc.2010.11.073
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发表时间：
2011-07-12
影响因子：
24
通讯作者：
Kestenbaum, Bryan
中科院分区：
文献类型：
--
作者：
Linefsky, Jason P.;O'Brien, Kevin D.;Katz, Ronit;de Boer, Ian H.;Barasch, Eddy;Jenny, Nancy S.;Siscovick, David S.;Kestenbaum, Bryan
评价矿物质代谢标志物作为钙化性主动脉瓣疾病的潜在危险因素。矿物质代谢紊乱在老年人中很常见，并可能导致心脏瓣膜钙化。血清矿物质代谢标志物与心脏瓣膜钙化的关系尚未在特征明确的老年人人群中进行评估。我们测量了1,938名心血管健康研究参与者的血清磷酸盐、钙、甲状旁腺激素和25-羟基维生素D水平，这些参与者没有临床心血管疾病，并接受了主动脉瓣硬化（AVS）、二尖瓣环钙化（MAC）和主动脉瓣环钙化（AAC）的超声心动图测量。在校正相关混杂变量（包括肾功能）后，我们使用逻辑回归模型估计矿物质代谢标志物与AVS、MAC和AAC的相关性。AVS、MAC和AAC的患病率分别为54%、39%和44%。血清磷浓度每升高0.5 mg/dl，（比值比1.17，95%置信区间1.04至1.31，p = 0.01），MAC（比值比1.12，95%置信区间1.00至1.26，p =0.05）和AAC（比值比1.12，95%置信区间0.99至1.25，p = 0.05）。相反，血清钙、甲状旁腺激素和25-羟基维生素D浓度与主动脉瓣或二尖瓣钙化无关。正常范围内较高的血清磷酸盐水平与社区老年人队列中瓣膜和瓣环钙化相关。磷酸盐可能是钙化性主动脉瓣疾病的一个新的危险因素，值得进一步研究。
To evaluate mineral metabolism markers as potential risk factors for calcific aortic valve disease. Mineral metabolism disturbances are common among older people and may contribute to cardiac valvular calcification. Associations of serum mineral metabolism markers with cardiac valvular calcification have not been evaluated in a well-characterized general population of older adults. We measured serum levels of phosphate, calcium, parathyroid hormone, and 25-hydroxyvitamin D in 1,938 Cardiovascular Health Study participants who were free of clinical cardiovascular disease and who underwent echocardiography measurements of aortic valve sclerosis (AVS), mitral annular calcification (MAC), and aortic annular calcification (AAC). We used logistic regression models to estimate associations of mineral metabolism markers with AVS, MAC, and AAC after adjustment for relevant confounding variables, including kidney function. The respective prevalences of AVS, MAC, and AAC were 54%, 39%, and 44%. Each 0.5 mg/dl higher serum phosphate concentration was associated with a greater adjusted odds of AVS (odds ratio 1.17, 95% confidence interval 1.04 to 1.31, p = 0.01), MAC (odds ratio 1.12, 95% confidence interval 1.00 to 1.26, p =0.05), and AAC (odds ratio 1.12, 95% confidence interval 0.99 to 1.25, p = 0.05). In contrast, serum calcium, parathyroid hormone, and 25-hydroxyvitamin D concentrations were not associated with aortic or mitral calcification. Higher serum phosphate levels within the normal range are associated with valvular and annular calcification in a community-based cohort of older adults. Phosphate may be a novel risk factor for calcific aortic valve disease and warrants further study.
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影响因子：
20.1
作者：
Li, XW;Yang, HY;Giachelli, CM
通讯作者：
Giachelli, CM
影响因子：
4.8
作者：
Foley, Robert N.;Collins, Allan J.;Kalra, Philip A.
通讯作者：
Kalra, Philip A.
DOI：
10.1016/j.echo.2006.01.026
发表时间：
2006-07-01
影响因子：
6.5
作者：
Kume, Teruyoshi;Kawamoto, Takahiro;Yoshida, Kiyoshi
通讯作者：
Yoshida, Kiyoshi
影响因子：
4.8
作者：
Barasch, E;Gottdiener, JS;Manolio, TA
通讯作者：
Manolio, TA
影响因子：
37.8
作者：
Hagstrom, Emil;Hellman, Per;Arnlov, Johan
通讯作者：
Arnlov, Johan