Short Report: A Comparative Study of Clinical Features between Monotypic and Dual Infection Cases with Chikungunya Virus and Dengue Virus in West Bengal, India
Short Report: A Comparative Study of Clinical Features between Monotypic and Dual Infection Cases with Chikungunya Virus and Dengue Virus in West Bengal, India
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DOI：
10.4269/ajtmh.2012.11-0704
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发表时间：
2012-04-01
影响因子：
3.3
通讯作者：
Chatterjee, Shyamalendu
中科院分区：
文献类型：
--
作者：
Taraphdar, Debjani;Sarkar, Arindam;Chatterjee, Shyamalendu
基孔肯雅病毒(CHIKV)和登革热病毒(DENV)分别在印度西孟加拉邦传播。然而，1965年后，两种病毒造成的双重感染直到2010年才被记录下来。2010年，对发热病例进行了调查，以确认这两种病毒同时参与。对550份血样进行了CHIKV和DENV免疫球蛋白M(IgM)抗体检测。经酶联免疫吸附试验检测，131例(23.8%)和104例(18.9%)患者同时检测到CHIKV和DENV抗体，68例(12.4%)同时检测到CHIKV和DENV抗体。发热、关节痛、皮疹、头痛、肌肉痛和恶心/呕吐是单型和双重感染的共同特征。严重关节疼痛和关节肿胀仅见于CHIKV阳性病例，腹痛主要与DENV感染有关。腹泻仅由双重感染患者报告(16.2%)。
Chikungunya virus (CHIKV) and dengue virus (DENV) are circulating individually in the state of West Bengal, India. However, after 1965 the dual-infection caused by both viruses had not been recorded until 2010. In 2010, an investigation of the febrile cases was carried out to confirm the involvement of both viruses simultaneously. A total of 550 blood samples were tested for the detection of immunoglobulin M (IgM) antibody against both CHIKV and DENV. Serology by the enzyme-linked immunosorbent assay method confirmed that 131 (23.8%) and 104 (18.9%) patients had IgM antibody against CHIKV and DENV, respectively, whereas 68 (12.4%) had IgM antibodies against both CHIKV and DENV. Fever, joint pain, rashes, headache, myalgia, and nausea/vomiting are the common features in the case of both monotypic and dual-infection. Severe arthralgia and swelling of joints were common only in CHIKV-positive cases and abdominal pain was mainly associated with DENV infection. Diarrhea was reported only by the dual-infected patients (16.2%).