Effect of excitatory amino acid, dopamine, and oxytocin receptor antagonists on noncontact penile erections and paraventricular nitric oxide production in male rats.
Effect of excitatory amino acid, dopamine, and oxytocin receptor antagonists on noncontact penile erections and paraventricular nitric oxide production in male rats.
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兴奋性氨基酸、多巴胺和催产素受体拮抗剂对雄性大鼠非接触性阴茎勃起和室旁一氧化氮产生的影响。
作者：
M. R. Melis;S. Succu;M. S. Spano;A. Argiolas
在雄性大鼠中，非接触性勃起伴随着下丘脑室旁核（PVN）中NO2-和NO3-的增加而发生。在本研究中，地佐环平、（+）-MK-801（1 μ g和5 μ g）阻断PVN兴奋性氨基酸受体可降低这两种反应，但6-氰基-7-硝基-喹喔啉-2，3-二酮（5 μ g）或（+）-2-氨基-4-膦酰基-丁酸（5 μ g）不会降低。当注射到PVN时，多巴胺拮抗剂SCH 23390（5 μ g）、S（+）-雷氯必利（10 μ g）、顺式氟噻吨（10 μ g）以及催产素拮抗剂d（CH 2）5 Tyr（Me）2-Om 8-vasotocin（1 μ g）也无效。然而，当最后一种药物被注入侧脑室时，它减少了非接触性勃起，而没有改变NO2-和NO3-的增加。这些结果表明，兴奋性氨基酸的传输增加在PVN在非接触性勃起。这可能有助于增加PVN中NO的产生，并且它可能激活介导这种性反应的催产素神经元。
In male rats, noncontact erections occur concomitantly with an increase in NO2- and NO3- in the paraventricular nucleus of the hypothalamus (PVN). In the present study, both responses were reduced by the blockade of PVN excitatory amino acid receptors by dizocilpine, (+)-MK-801(1 and 5 microg), but not by 6-cyano-7-nitro-quinoxaline-2,3-dione (5 microg) or (+)-2-amino-4-phosphono-butanoic acid (5 microg). Also ineffective when injected into the PVN were the dopamine antagonists SCH 23390 (5 microg), S(+)-raclopride (10 microg), and cis-flupenthixol (10 microg), and the oxytocin antagonist d(CH2)5Tyr(Me)2-Om8-vasotocin (1 microg). However, when the last was given into the lateral ventricles, it reduced noncontact erections without modifying NO2- and NO3- increases. These results suggest that excitatory amino acid transmission increases in the PVN during noncontact erections. This may contribute to increased NO production in the PVN, and it may activate oxytocin neurons mediating this sexual response.
DOI：
10.1111/j.1399-3011.1980.tb02962.x
发表时间：
2009-01
期刊：
International journal of peptide and protein research
影响因子：
--
作者：
K. Bańkowski;M. Manning;J. Seto;J. Haldar;Wilbur H. Sawyer
通讯作者：
K. Bańkowski;M. Manning;J. Seto;J. Haldar;Wilbur H. Sawyer
改变阿片类药物耐受性、身体依赖性、戒断综合症和自我管理行为的药物的多样性。
影响因子：
21.1
作者：
Bhargava,HN
通讯作者：
Bhargava,HN