The growing repertoire of genetic tools for dissecting chlamydial pathogenesis.
The growing repertoire of genetic tools for dissecting chlamydial pathogenesis.
复制标题
用于剖析衣原体发病机制的遗传工具不断增多。
DOI：
10.1093/femspd/ftab025
复制
发表时间：
2021
影响因子：
3.3
通讯作者：
Nelson,DavidE
中科院分区：
文献类型：
--
作者：
Banerjee,Arkaprabha;Nelson,DavidE
衣原体属中的多种专性胞内细菌是重要的兽医和/或人类病原体。这些病原体都有相似的双相发育周期和细胞内营养网状体和感染性基本形式之间的过渡，但在其宿主偏好和致病潜力方面差异很大。长期以来，缺乏对这些生物体进行基因工程的工具一直是研究其生物学和发病机制的障碍。然而，在C.沙眼在过去的10年里，以及这些方法中的一些方法对其他衣原体的适应。在过去的几年里，为研究这一普遍存在的重要病原体开辟了令人兴奋的新的可能性。
Multiple species of obligate intracellular bacteria in the genusChlamydiaare important veterinary and/or human pathogens. These pathogens all share similar biphasic developmental cycles and transition between intracellular vegetative reticulate bodies and infectious elementary forms, but vary substantially in their host preferences and pathogenic potential. A lack of tools for genetic engineering of these organisms has long been an impediment to the study of their biology and pathogenesis. However, the refinement of approaches developed inC. trachomatisover the last 10 years, and adaptation of some of these approaches to otherChlamydiaspp. in just the last few years, has opened exciting new possibilities for studying this ubiquitous group of important pathogens.