The effects of RAMPs upon cell signalling
The effects of RAMPs upon cell signalling
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DOI：
10.1016/j.mce.2017.03.033
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发表时间：
2017-07
影响因子：
4.1
通讯作者：
S. Routledge;G. Ladds;D. Poyner
中科院分区：
文献类型：
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作者：
S. Routledge;G. Ladds;D. Poyner
G蛋白偶联受体（GPCRs）在信号转导中起着重要作用。现在很清楚，细胞内和细胞表面的许多其他分子与GPCR相互作用以调节其信号传导特性。受体活性修饰蛋白（receptor activity modifying proteins，RAMP）是一类具有单一跨膜结构域的蛋白质，主要与B家族GPCR相互作用，但与A、C家族受体的相互作用最近才开始出现。这些相互作用可以影响细胞表面表达、配体结合偏好和G蛋白偶联，从而调节GPCR信号转导。对于RAMP对GPCR信号传导的影响，仍有大量研究有待进行;除了它们与家族A和C GPCR的潜在相互作用之外，它们对家族B GPCR的影响仍没有完全记录。新的相互作用可能对治疗方法的发展产生重大影响。
G protein-coupled receptors (GPCRs) play a vital role in signal transduction. It is now clear that numerous other molecules within the cell and at the cell surface interact with GPCRs to modulate their signalling properties. Receptor activity modifying proteins (RAMPs) are a group of single transmembrane domain proteins which have been predominantly demonstrated to interact with Family B GPCRs, but interactions with Family A and C receptors have recently begun to emerge. These interactions can influence cell surface expression, ligand binding preferences and G protein-coupling, thus modulating GPCR signal transduction. There is still a great deal of research to be conducted into the effects of RAMPs on GPCR signalling; their effects upon Family B GPCRs are still not fully documented, in addition to their potential interactions with Family A and C GPCRs. New interactions could have a significant impact on the development of therapeutics.