Allergic nephropathy associated with norfloxacin and ciprofloxacin therapy - Report of two cases and review of the literature
Allergic nephropathy associated with norfloxacin and ciprofloxacin therapy - Report of two cases and review of the literature
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DOI：
10.3109/00365599709030647
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发表时间：
1997-10-01
影响因子：
--
通讯作者：
Lindell, A
中科院分区：
文献类型：
--
作者：
Hadimeri, H;Almroth, G;Lindell, A
与喹诺酮类抗生素相关的变应性肾病的报告越来越多。其机制可能是超敏反应。诺氟沙星以前仅被认为是一次病因，急性间质性肾炎（AIN）是组织病理学发现。在28例病例中报告了环丙沙星相关肾病，AIN是主要的组织病理学发现。本报告描述了与诺氟沙星治疗相关的第二例AIN和另一例环丙沙星相关的肾间质药物不良反应。临床医生应了解喹诺酮类药物相关AIN，这是一种罕见但具有潜在危险的肾脏并发症。
Allergic nephropathy associated with quinolone antibiotics has been reported in an increasing number of cases. The mechanism might be a hypersensitivity reaction. Norfloxacin has been incriminated previously as a cause once only, with acute interstitial nephritis (AIN) as the histopathological finding. Ciprofloxacin-associated nephropathy has been reported in 28 cases, with AIN as the main histopathological finding. This report describes a second case of AIN associated with norfloxacin treatment and another ciprofloxacin-associated renal interstitial drug adverse reaction. Clinicians should be aware of quinolone-associated AIN, which is a rare but potentially dangerous renal complication.