A prospective study of the antiemetic effect of palonosetron in malignant lymphoma patients treated with the CHOP regimen.
A prospective study of the antiemetic effect of palonosetron in malignant lymphoma patients treated with the CHOP regimen.
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帕洛诺司琼对接受 CHOP 方案治疗的恶性淋巴瘤患者止吐作用的前瞻性研究。
DOI：
10.1007/s12185-016-2089-9
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发表时间：
2016
期刊：
影响因子：
2.1
通讯作者：
Minami H.
中科院分区：
文献类型：
--
作者：
Miyata Y;Yakushijin K;Inui Y;Imamura Y;Goto H;Mizutani Y;Kurata K;Kakiuchi S;Sanada Y;Minami Y;Kawamoto S;Yamamoto K;Ito M;Tominaga R;Gomyo H;Mizuno I;Nomura T;Kitagawa K;Sugimoto T;Murayama T;Matsuoka H;Minami H.
为了确定减少CHOP方案（包括大剂量类固醇）引起的呕吐的策略，我们前瞻性地评估了帕洛诺司琼在日本患者中的疗效。帕洛诺司琼在第1天化疗前30分钟静脉注射0.75 mg。患者从化疗开始至化疗后168 h记录化疗引起的恶心呕吐（CINV）发生率，记录恶心、呕吐、厌食的发生及严重程度，以及抢救用药情况。主要终点是恶心、呕吐和厌食症的总发生率；这些比率分别为56%，12%和62%，包括所有年级。口服强的松龙120 ~ 168 h后，症状发生率和严重程度趋于恶化。我们将完全缓解（CR）定义为无呕吐和不使用抢救治疗。帕洛诺司琼0.75 mg治疗后急性期（0 ~ 24 h）、延迟期（24 ~ 168 h）和总期（0 ~ 168 h）的CR率分别为86.6%、66%和62%。CHOP方案在第6天及以后的止吐策略应进行研究。
To identify strategies for reducing emesis induced by the CHOP regimen, which includes high-dose steroids, we prospectively evaluated the efficacy of palonosetron in Japanese patients. Palonosetron was administered at a dose of 0.75 mg via intravenous injection over 30 min before chemotherapy on day 1. Patients kept diaries of chemotherapy-induced nausea and vomiting (CINV) incidence from the start of chemotherapy until 168 h afterwards, in which they documented the occurrence and severity of nausea, vomiting, anorexia, and the use of rescue medication. The primary endpoint was the overall occurrence rate of nausea, vomiting, and anorexia; these rates were 56, 12, and 62 %, respectively, including all grades. The rates and severity of symptoms tended to worsen 120–168 h after completing oral prednisolone. We defined complete response (CR) as no vomiting and no use of rescue therapy. The CR rates of post palonosetron 0.75 mg treatment in the acute (0–24 h), delayed (24–168 h), and overall phases (0–168 h) were 86, 66, and 62 %, respectively. Antiemetic strategies of CHOP regimen for day 6 and, thereafter, should be investigated.