AGING AND CROSS LINKING IN MAMMALIAN COLLAGEN
AGING AND CROSS LINKING IN MAMMALIAN COLLAGEN
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DOI：
10.1080/03610737708257091
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发表时间：
1977-01-01
影响因子：
1.8
通讯作者：
DAVISON P F
中科院分区：
文献类型：
--
作者：
CANNON D J;DAVISON P F
检查胶原蛋白中硼氢化物可还原交联的数量和类型作为动物年龄的函数。在各种牛、犬和人体组织中，可还原交联的水平随着时间的推移而降低，并且各个化合物的比例也发生变化。这些变化的程度具有组织和物种特异性。可还原交联水平的降低与生长停止相关。可还原交联的损失并不意味着交联总数较少，因为随着时间的推移而发生的物理变化意味着相反的情况。可还原交联显然转化为稳定的不可还原状态，并且低水平可还原交联的持续存在可能表明组织中的周转水平较低。可还原交联比率的变化具有可疑的功能意义，并且可能仅反映赖氨酸残基翻译后修饰的变化。
The amount and type of borohydride-reducible crosslinks in collagen were examined as a function of animal age. In a variety of bovine, canine and human tissues, the level of reducible crosslinks decreases with time and the ratios of individual compounds change. There is both tissue and species specificity in the extent of these changes. A decrease in the level of reducible crosslinks correlates with the cessation of growth. Loss of reducible crosslinks does not imply a small total number of crosslinks since physical changes with age imply the opposite. Reducible crosslinks are apparently converted to a stable nonreducible state and the persistence of low levels of reducible crosslinks may be indicative of a low level of turnover in the tissue. Changes in ratios of reducible crosslinks are of doubtful functional significance and may simply reflect variation in post-translational modification of lysine residues.