The effects of birth weight on basal cardiovascular function in pigs at 3 months of age
The effects of birth weight on basal cardiovascular function in pigs at 3 months of age
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DOI：
10.1113/jphysiol.2001.012926
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发表时间：
2002-03-15
影响因子：
5.5
通讯作者：
Fowden, AL
中科院分区：
文献类型：
--
作者：
Poore, KR;Forhead, AJ;Fowden, AL
对于男性，流行病学研究表明，低出生体重 (BW) 与晚年患心血管疾病的风险增加有关。在这项研究中，研究了自然体重变化对出生后 3 个月的猪基础心血管功能的长期影响。从总共 12 窝 3 个月大的仔猪中选择低体重（< 1.41 kg；n = 20）和高体重（> 1.52 kg；n = 20）大白仔猪进行研究。使用标准记录设备记录基础平均动脉压（MAP）和心率（HR）大约30分钟，并采集基础动脉血样进行激素分析。还测量了肾脏、肺和血浆中血管紧张素转换酶（ACE）的浓度。 3 月龄猪的基础 MAP（而非 HR）与体重显着负相关，与头长与体重之比正相关。低体重猪的出生后生长速度比高体重猪慢，因此低体重仔猪在 3 个月龄时仍然明显较小。低体重猪和高体重猪之间的基础血浆肾上腺素或皮质醇浓度没有差异。然而，与高体重猪相比，低体重猪的基础血浆去甲肾上腺素浓度显着升高。与高体重猪相比，低体重猪的肾和肺 ACE 水平显着降低。这些数据表明，3 月龄猪的基础 MAP 与体重呈负相关，与出生时体型不成比例呈正相关。这种效应与基础血浆去甲肾上腺素浓度的增加有关。
In man, epidemiological studies have shown that low birth weight (BW) is associated with an increased risk of cardiovascular disease in later life. In this study, the long-term consequences of variations in natural BW on basal cardiovascular function were investigated in pigs at 3 months of postnatal age. Low (< 1.41 kg; n = 20) and high (> 1.52 kg; n = 20) BW Large White piglets were selected from a total of 12 litters for study at 3 months of age. Basal mean arterial pressure (MAP) and heart rate (HR) were recorded for similar to30 min using standard recording equipment and basal arterial blood samples were taken for hormone analyses. Concentrations of angiotensin-converting enzyme (ACE) were also measured in kidney, lung and plasma. Basal MAP, but not HR, in 3-month-old pigs was significantly inversely related to BW and positively related to the ratio of head length to BW. Postnatal growth rate of low BW pigs was slower than that of high BW pigs such that low BW piglets remained significantly smaller at 3 months of age. There were no differences in basal plasma adrenaline or cortisol concentrations between low and high BW pigs. However, basal plasma noradrenaline concentrations were significantly elevated in low BW compared to high BW pigs. Renal and pulmonary ACE levels were significantly reduced in low BW compared to high BW pigs. These data show that basal MAP in 3-month-old pigs is negatively associated with BW and positively correlated to disproportionate size at birth. This effect was associated with an increase in basal plasma noradrenaline concentrations.