Atrophy of the Cholinergic Basal Forebrain can Detect Presynaptic Cholinergic Loss in Parkinson's Disease.
Atrophy of the Cholinergic Basal Forebrain can Detect Presynaptic Cholinergic Loss in Parkinson's Disease.
复制标题
胆碱能基底前脑萎缩可以检测帕金森病的突触前胆碱能丧失。
DOI：
10.1002/ana.26596
复制
发表时间：
2023
影响因子：
11.2
通讯作者：
Bohnen,NicolaasI
中科院分区：
文献类型：
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作者：
Ray,NicolaJ;Kanel,Prabesh;Bohnen,NicolaasI
胆碱能基底前脑的结构成像可能提供胆碱能系统完整性的生物标志物，可用于帕金森病的运动和非运动结局研究。然而，没有先前的研究已经验证了这些结构指标与帕金森氏病的胆碱能神经末梢在体内成像。在这里，我们相关的胆碱能基底前脑形态与地形的囊泡乙酰胆碱转运体在一个大的Parkinson sample.Methods[18 F]-氟乙氧基苯甲酰维索霉素囊泡乙酰胆碱转运体正电子发射断层扫描进行了101非痴呆症的人帕金森氏症（76.24%男性，平均年龄67.6 ± 7.72岁，病程5.7 ± 4.4年）。次区域胆碱能基底前脑体积采用磁共振成像形态测量。通过基于相关性analysis.ResultsSubregional量的胆碱能基底前脑预测胆碱能神经末梢损失，最强大的相关性发生在后胆碱能基底前脑和颞额，颞叶，扣带回，海马区之间，并与适度的相关性在顶枕区。海马相关性并不限于胆碱能基底前脑亚区Ch 1 - 2。相关性也观察到在纹状体，丘脑，和brainstem.InterpretationCholinergic基底前脑形态是一个强大的预测区域脑泡乙酰胆碱转运体结合，特别是在前脑。顶枕结合和基底前脑体积之间相对缺乏相关性可能反映了后皮质中存在更多弥漫性突触病，其病因远远超出胆碱能系统。神经网络2023;93：991-998
ObjectivesStructural imaging of the cholinergic basal forebrain may provide a biomarker for cholinergic system integrity that can be used in motor and non‐motor outcome studies in Parkinson's disease. However, no prior studies have validated these structural metrics with cholinergic nerve terminal in vivo imaging in Parkinson's disease. Here, we correlate cholinergic basal forebrain morphometry with the topography of vesicular acetylcholine transporter in a large Parkinson's sample.Methods[18F]‐Fluoroethoxybenzovesamicol vesicular acetylcholine transporter positron emission tomography was carried out in 101 non‐demented people with Parkinson's (76.24% male, mean age 67.6 ± 7.72 years, disease duration 5.7 ± 4.4 years). Subregional cholinergic basal forebrain volumes were measured using magnetic resonance imaging morphometry. Relationships were assessed via volume‐of‐interest based correlation analysis.ResultsSubregional volumes of the cholinergic basal forebrain predicted cholinergic nerve terminal loss, with most robust correlations occurring between the posterior cholinergic basal forebrain and temporofrontal, insula, cingulum, and hippocampal regions, and with modest correlations in parieto‐occipital regions. Hippocampal correlations were not limited to the cholinergic basal forebrain subregion Ch1‐2. Correlations were also observed in the striatum, thalamus, and brainstem.InterpretationCholinergic basal forebrain morphometry is a robust predictor of regional cerebral vesicular acetylcholine transporter bindings, especially in the anterior brain. The relative lack of correlation between parieto‐occipital binding and basal forebrain volumes may reflect the presence of more diffuse synaptopathy in the posterior cortex due to etiologies that extend well beyond the cholinergic system. ANN NEUROL 2023;93:991–998