Prognostic significance of TCF21 mRNA expression in patients with lung adenocarcinoma.
Prognostic significance of TCF21 mRNA expression in patients with lung adenocarcinoma.
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TCF21 mRNA表达在肺腺癌患者中的预后意义
DOI：
10.1038/s41598-017-02290-2
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发表时间：
2017-05-17
影响因子：
4.6
通讯作者：
Chen Q
中科院分区：
文献类型：
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作者：
Xiao J;Liu A;Lu X;Chen X;Li W;He S;He B;Chen Q
一些预后指标在不同性别的肺腺癌患者中显示不一致，表明这些差异可能是由于男性和女性肺腺癌患者的遗传背景不同。在本研究中，我们首先利用生物技术信息基因云（GCBI）生物信息学平台，鉴定了消除肺腺癌和正常肺组织性别差异的差异表达基因（DEGs）。然后，我们通过在GCBI平台上创建基因共表达网络，筛选出转录因子21 （TCF21）是这些deg中的枢纽基因。此外，我们使用Kaplan-Meier绘图仪和PrognoScan综合生存分析平台评估TCF21表达在肺腺癌患者中的预后价值。最后，我们得出结论，TCF21 mRNA表达降低是肺腺癌患者预后不良的预测因子。
Several prognostic indicators have shown inconsistencies in patients of different genders with lung adenocarcinoma, indicating that these variations may be due to the different genetic background of males and females with lung adenocarcinoma. In this study, we first used the Gene-Cloud of Biotechnology Information (GCBI) bioinformatics platform to identify differentially expressed genes (DEGs) that eliminated gender differences between lung adenocarcinoma and normal lung tissues. Then, we screened out that transcription factor 21 (TCF21) is a hub gene among these DEGs by creating a gene co-expression network on the GCBI platform. Furthermore, we used the comprehensive survival analysis platforms Kaplan-Meier plotter and PrognoScan to assess the prognostic value of TCF21 expression in lung adenocarcinoma patients. Finally, we concluded that decreased mRNA expression of TCF21 is a predictor for poor prognosis in patients with lung adenocarcinoma.