Geometry of a Weight-Bearing and Non-Weight-Bearing Bone in the Legs of Young, Old, and Very Old Men
Geometry of a Weight-Bearing and Non-Weight-Bearing Bone in the Legs of Young, Old, and Very Old Men
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DOI：
10.1007/s00223-009-9261-7
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发表时间：
2009-07-01
影响因子：
4.2
通讯作者：
Rice, Charles L.
中科院分区：
文献类型：
--
作者：
McNeil, Chris J.;Raymer, Graydon H.;Rice, Charles L.
骨几何形状是骨强度的重要决定因素，并受肌肉牵拉和负重的影响。肌肉质量和暴露于负重随着年龄的增长而减少，因此本研究的目的是比较不同年龄组腿部负重（胫骨）和非负重（腓骨）骨的骨几何结构。在13名年轻人（26岁），13名老年人（66岁）和13名极老年人（83岁）中获得了右腿的磁共振图像。在大约腿长的三分之一和三分之二处测量骨的皮质、髓质和总横截面积（CSA）。在近端部位测量前、侧和后室的肌肉CSA。老年人胫骨皮质CSA相似，小14 - 22%，但腓骨各年龄组相似。两种骨的髓样CSA随年龄增长而增大（相似于5%至65%），但胫骨的髓样CSA比腓骨大15%至440%。两种骨骼的总CSA在不同年龄段相似。年轻人和老年人的肌肉质量相似，但老年人的肌肉质量大约低25%，因此，两个老年组近端和远端部位骨几何形状的差异程度各不相同。这些发现表明，肌肉拉伸和负重之间存在复杂的年龄依赖性相互作用。胫骨中骨几何结构的较大年龄相关差异表明胫骨的承重作用使其比腓骨更容易受到通常与衰老相关的活动减少的影响。
Bone geometry is an important determinant of bone strength and is influenced by muscle pull and weight-bearing. Muscle mass and exposure to weight-bearing decrease with age and thus the purpose of the study was to compare bone geometry of the weight-bearing (tibia) and non-weight-bearing (fibula) bones of the leg in different age groups. Magnetic resonance images of the right leg were acquired in 13 young (26 yr), 13 old (66 yr), and 13 very old men (83 yr). Cortical, medullary and total cross-sectional areas (CSA) of the bones were measured at approximately one-third and two-thirds the length of the leg. Muscle CSA of the anterior, lateral and posterior compartments was measured at the proximal site. Cortical CSA was similar to 14 to 22% smaller in the elderly in the tibia but similar across age in the fibula. Medullary CSA was larger with age (similar to 5 to 65%) in both bones but similar to 15 to 440% greater in the tibia than fibula. Total CSA was similar across age in both bones. Muscle mass was similar between young and old but similar to 25% less in the very old and as a consequence, the magnitude of differences in bone geometry at proximal and distal sites varied in the two elderly groups. These findings indicate that there is a complex age-dependent interaction between muscle pull and weight-bearing. The greater age-related differences in bone geometry in the tibia suggest the weight-bearing role of the tibia makes it more susceptible than the fibula to the reduced activity typically associated with aging.