Regional cerebral blood flow correlates with heart period and high-frequency heart period variability during working-memory tasks: Implications for the cortical and subcortical regulation of cardiac autonomic activity
Regional cerebral blood flow correlates with heart period and high-frequency heart period variability during working-memory tasks: Implications for the cortical and subcortical regulation of cardiac autonomic activity
复制标题
DOI：
10.1111/1469-8986.2004.00179.x
复制
发表时间：
2004-07-01
期刊：
影响因子：
3.7
通讯作者：
Jennings, JR
中科院分区：
文献类型：
--
作者：
Gianaros, PJ;Van Der Veen, FM;Jennings, JR
本研究的目的是描述人类行为诱发的局部脑激活和心脏自主活动之间的功能关系。同时估计局部脑血流量（rCBF;通过正电子发射断层扫描获得），心脏周期和高频心脏周期变异性（HF-HPV-1心脏副交感神经活动的指标）进行了检查93名成年人（年龄50-70岁）谁执行了一系列越来越困难的工作记忆任务。任务难度增加导致心动周期减少（表明心脏加速）和HF-HPV减少（表明心脏副交感神经活动减少）。任务引起的心动周期和HF-HPV的减少与皮质和皮质下脑区的rCBF的同时增加和减少相关，这些脑区被推测在行为过程中调节心脏自主活动：内侧前额叶、岛叶和前扣带皮质、杏仁核-海马复合体和小脑。这些发现重复和扩展了少数功能性神经影像学研究，这些研究表明皮质和皮质下脑系统在人类心脏自主调节中的所有重要作用。
The aim of the present study was to characterize the functional relationships between behaviorally evoked regional brain activation and cardiac autonomic activity in humans. Concurrent estimates of regional cerebral blood flow (rCBF; obtained by positron emission tomography), heart period, and high-frequency heart period variability (HF-HPV-1 an indicator of cardiac parasympathetic activity) were examined in 93 adults (aged 50-70 years) who performed a series of increasingly difficult working-memory tasks. Increased task difficulty resulted in decreased heart period (indicating cardioacceleration) and decreased HF-HPV (indicating decreased cardiac parasympathetic activity). Task-induced decreases in heart period and HF-HPV were associated with concurrent increases and decreases in rCBF to cortical and subcortical brain regions that are speculated to regulate cardiac autonomic activity during behavioral processes: the medial-prefrontal, insular, and anterior cingulate cortices, the amygdala-hippocampal complex, and the cerebellum. These findings replicate and extend a small number of functional neuroimaging studies that suggest all important role for both cortical and subcortical brain systems in human cardiac autonomic regulation.