Bone health of patients with juvenile idiopathic arthritis: a comparison between dual-energy X-ray absorptiometry and digital X-ray radiogrammetry
Bone health of patients with juvenile idiopathic arthritis: a comparison between dual-energy X-ray absorptiometry and digital X-ray radiogrammetry
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DOI：
10.1016/j.ejrad.2015.06.015
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发表时间：
2015-10-01
影响因子：
3.3
通讯作者：
van Sunlekom-Smit, Lisette W. A.
中科院分区：
文献类型：
--
作者：
Nusman, Charlotte M.;Anink, Janneke;van Sunlekom-Smit, Lisette W. A.
目的：幼年特发性关节炎（JIA）影响骨密度（BMD）。双能X线骨密度仪（DXA）是最广泛使用的测定BMD的技术。数字X线摄影测量（DXR）是一种可行的方法来确定骨密度的手片。本研究旨在比较DXR和DXA在评估骨密度在JIA patients.Methods：35例JIA患者提供DXA和手X线片在同一时间段内被列入荷兰关节炎和生物制品在儿童注册。BMD的测量结果是DXR的骨健康指数和DXA的全身BMD、腰椎BMD和骨矿物质表观密度。将所有测量值转换为Z评分。相关性进行了评估与Pearson相关系数。结果：患者的中位年龄（60%女性）为11.7岁。绝对评分的Pearson相关系数为0.568-0.770（p < 0.001）。DXA和DXR.Conclusions的Z-分数之间没有显着的相关性：从DXR的BMD评估相关的DXA措施在一个队列的JIA患者，虽然只有在绝对分数。在临床实践中实施DXR的未来步骤包括评价对变化的反应性、预测价值以及与其他成像技术的比较。(C)2015爱思唯尔爱尔兰有限公司版权所有。
Objectives: Juvenile idiopathic arthritis (JIA) affects bone mineral density (BMD). Dual-energy X-ray absorptiometry (DXA) is the most widely used technique to determine BMD. Digital X-ray radiogrammetry (DXR) is a feasible method for determination of cortical BMD on hand radiographs. This study aimed to compare DXR and DXA in the assessment of BMD in JIA patients.Methods: Thirty-five JIA patients with available DXA and hand radiograph within the same time period were included from the Dutch Arthritis and Biologicals in Children register. Outcome measures for BMD were Bone Health Index from DXR and BMD total body, BMD lumbar spine and Bone Mineral Apparent Density from DXA. All measures were transformed to Z-scores. Correlations were assessed with Pearson correlation coefficients.Results: Median age of the patients (60% female) was 11.7 years. Pearson correlation coefficient was significant for the absolute scores: 0.568-0.770 (p < 0.001). No significant correlation was found between the Z-scores of DXA and DXR.Conclusions: The BMD assessment from the DXR was correlated to DXA measures in a cohort of JIA patients, although only in absolute scores. Future steps for implementation of DXR in clinical practice include evaluation of responsiveness to change, predictive value and comparison with other imaging techniques. (C) 2015 Elsevier Ireland Ltd. All rights reserved.