Clinical significance of serum omentin-1 levels in patients with pancreatic adenocarcinoma.
Clinical significance of serum omentin-1 levels in patients with pancreatic adenocarcinoma.
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DOI：
10.1016/j.bbacli.2016.10.002
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发表时间：
2016-12
期刊：
影响因子：
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通讯作者：
Tas, Faruk
中科院分区：
文献类型：
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作者：
Karabulut, Senem;Afsar, Cigdem Usul;Karabulut, Mehmet;Alis, Halil;Bozkurt, Mehmet Abdussamet;Aydogan, Fatma;Serilmez, Murat;Tas, Faruk
Omentin与代谢综合征和肥胖有关。胰腺腺癌（PA）是一种与肥胖相关的致死性恶性肿瘤。本研究旨在探讨PA患者血清大网膜蛋白水平及其与肿瘤进展和已知预后参数的关系。在接受任何治疗前，从33名患者首次入院时获得血清样本。年龄、性别和身体质量指数（BMI）相匹配的30名健康对照者被纳入分析。采用酶联免疫吸附试验（ELISA）测定两组血清大网膜蛋白水平。诊断时的中位年龄为59岁（32-84岁）。20例（61%）患者为男性，其余为女性。23例转移患者中最常见的转移部位是肝脏（n = 19.83%）。在接受姑息性化疗（CTx）的23名转移性患者中，39%的患者对CTx有反应。全组中位总生存期为41.3±8.3周[95%可信区间(CI) = 25-58周]。PA患者的基线血清网膜蛋白水平显著高于对照组（p < 0.001）。病理肿瘤大小较大的患者血清网膜蛋白水平明显高于病理肿瘤大小较小的患者（p = 0.03）。相反，血清大网膜蛋白浓度对生存无预后作用（p = 0.54）。血清大网膜蛋白水平可能对PA患者有很好的诊断作用。我们想强调的事实是，我们的文章很重要，因为它是唯一一篇关于网膜水平和胰腺癌关系的文章。
Omentin is related with metabolic syndrome and obesity. Pancreatic adenocarcinoma (PA) is a lethal and obesity-linked malignancy. This study was conducted to investigate the serum levels of omentin in patients with PA and the relationship with tumor progression and known prognostic parameters. Serum samples were obtained from thirty-three patients on first admission before any treatment. Age, sex and body mass index (BMI) matched 30 healthy controls were included in the analysis. Both serum omentin levels were measured using enzyme-linked immunosorbent assay (ELISA). The median age at diagnosis was 59 years (32–84 years). Twenty (61%) patients were men and the remaining were women. The most common metastatic site was liver in 23 patients with metastasis (n = 19, 83%). Thirty-nine percent of 23 metastatic patients who received palliative chemotherapy (CTx) were CTx–responsive. Median overall survival of the whole group was 41.3 ± 8.3 weeks [95% confidence interval (CI) = 25–58 weeks]. The baseline serum omentin levels were significantly higher in patients with PA than in the control group (p < 0.001). Serum omentin levels were significantly higher in patients with larger pathologic tumor size compared with smaller size (p = 0.03). Conversely, serum omentin concentration was found to have no prognostic role on survival (p = 0.54). Serum levels of omentin may have a good diagnostic role in patients with PA. We want to emphasize the fact that our article is important because it is the only one about omentin levels and pancreatic cancer relationship.