Animal protein toxins: origins and therapeutic applications.
Animal protein toxins: origins and therapeutic applications.
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DOI：
10.1007/s41048-018-0067-x
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发表时间：
2018-01-01
影响因子：
--
通讯作者：
Wang, Feng
中科院分区：
文献类型：
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作者：
Chen, Na;Xu, Siqi;Wang, Feng
地球上的有毒动物已被发现是开发治疗方法的宝贵资源。酶和非酶蛋白质和肽是动物毒液的主要成分，其中许多可以靶向各种离子通道，受体和膜转运体。与传统的小分子药物相比，天然蛋白质和多肽对其靶点具有更高的特异性和效力。本文综述了几种具有代表性的有毒动物毒素的种类和特征，并介绍了动物毒素的成分及其在治疗人类疾病（包括癌症、神经退行性疾病、心血管疾病、神经性疼痛以及自身免疫性疾病）中的潜在候选药物的应用。同时，将新发现的毒素转化为临床应用还存在许多障碍。讨论了蛋白毒素类药物的发展面临的挑战、策略和前景。
Venomous animals on the earth have been found to be valuable resources for the development of therapeutics. Enzymatic and non-enzymatic proteins and peptides are the major components of animal venoms, many of which can target various ion channels, receptors, and membrane transporters. Compared to traditional small molecule drugs, natural proteins and peptides exhibit higher specificity and potency to their targets. In this review, we summarize the varieties and characteristics of toxins from a few representative venomous animals, and describe the components and applications of animal toxins as potential drug candidates in the treatment of human diseases, including cancer, neurodegenerative diseases, cardiovascular diseases, neuropathic pain, as well as autoimmune diseases. In the meantime, there are many obstacles to translate new toxin discovery to their clinical applications. The challenges, strategies, and perspectives in the development of the protein toxin-based drugs are discussed as well.