Re-localisation of a biopsy site in endoscopic images and characterisation of its uncertainty
Re-localisation of a biopsy site in endoscopic images and characterisation of its uncertainty
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DOI：
10.1016/j.media.2011.11.005
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发表时间：
2012-02-01
影响因子：
10.9
通讯作者：
Hawkes, David J.
中科院分区：
文献类型：
--
作者：
Allain, Baptiste;Hu, Mingxing;Hawkes, David J.
基于内窥镜引导探头的光学活检是一种用于组织活检和治疗的新方法。在检测之后，在内窥镜图像中向内窥镜医生提供视觉辅助可能是有用的，例如用于将钳子引导到光学检测到的活检部位。本文提出了一种在内窥镜检查中对这些部位进行定位的新方法。它利用内窥镜图像序列，其中活检部位位置是已知的，以便导出与序列中投射到需要计算重新定位的活检部位的后续目标图像上的图像相同数量的核线。通过最小化到核线的平方距离之和来找到重新定位的活检部位的位置。该方法还分析地确定了重新定位的活检部位的不确定性。这为内窥镜医生提供了重新定位的活检部位周围的置信度区域和重新定位精度的测量。模拟结果证实，分析不确定度有可能很好地估计实验不确定度。该方法在一个物理模型和来自四名患者的真实数据上进行了测试，这些患者在胃镜检查中获得了八个图像序列。重新定位的精确度和准确度估计为1毫米或更高，这足以重新定位光学活检部位。(C)2011爱思唯尔B.V.保留所有权利。
Endoscopy guided probe-based optical biopsy is a new method for detecting sites for tissue biopsy and treatment. After detection, it can be useful to provide a visual aid in the endoscopic images to the endoscopist for example for guidance of forceps to the biopsy sites detected optically. A new method for relocalisation of these sites during the endoscopic examination is presented in this paper. It makes use of a sequence of endoscopic images, where the biopsy site location is known, in order to derive the same number of epipolar lines as images in the sequence projected onto a subsequent target image where the re-localised biopsy site needs to be computed. The location of the re-localised biopsy site is found by minimisation of the sum of squared distances to the epipolar lines. The method also determines analytically the uncertainty of the re-localised biopsy site. This provides the endoscopist with a confidence region around the re-localised biopsy site and a measure of the re-localisation precision. Simulations confirmed that the analytical uncertainty has the potential to be a good estimation of the experimental uncertainty. The method was tested on a physical phantom and on real data from four patients with eight sequences of images acquired during gastroscopy. The re-localisation precision and accuracy were estimated at 1 millimetre or better, which is sufficient for re-localisation of optical biopsy sites. (C) 2011 Elsevier B.V. All rights reserved.