Role of co-expression of c-Myc, EZH2 and p27 in prognosis of prostate cancer patients after surgery
Role of co-expression of c-Myc, EZH2 and p27 in prognosis of prostate cancer patients after surgery
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c-Myc、EZH2和p27共表达对前列腺癌术后患者预后的影响
DOI：
10.3760/cma.j.issn.0366-6999.20122477
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发表时间：
2013-01-05
影响因子：
6.1
通讯作者：
Gao Xin
中科院分区：
文献类型：
--
作者：
Li Ke;Chen Ming-kun;Gao Xin
背景c-Myc、EZH 2和p27被认为是调节前列腺癌行为的重要因子，具有促肿瘤或抗肿瘤作用，并具有预测前列腺癌进展的能力，但关于它们的联合表达对预后价值的研究很少。方法采用免疫组化半定量方法检测129例中危前列腺癌组织中c-Myc、EZH 2和p27的表达水平，并与正常对照组比较。这三个标志物的表达谱进行了分析，并调查与生化recursion.Results的关联，在所有，129例中有50例经历了生化复发在中位随访时间为31个月（范围，6-60个月）。在这些复发患者中，观察到1例无任何单一阳性标志物，10例具有任何单一阳性标志物; 39例检测到任何两种或所有三种阳性标志物（22例具有任何两种，17例具有所有三种阳性标志物）。生存分析显示，c-Myc或EZH 2过表达，p27低表达的患者生化复发率显著增高。随后的多变量分析显示c-Myc、EZH 2和p27表达状态分别显示出预测复发的潜力。值得注意的是，将三种标志物组合在一起作为“复合指数”（0或1，对比2或3个阳性标志物）提供了强有力的预后价值（HR 6.57，95%CI 3.02-14.31，P
Background c-Myc, EZH2 and p27 were defined to modulate the behavior of prostate cancer with pro-tumoral or anti-tumoral effects and had ability in predicting prostate cancer progression, but the research of their co-expression value of prognosis is rarely. This study aimed to investigate the prognostic value of combining tri-marker together in patients with intermediate-risk prostate cancer after surgery.Methods Expression levels of c-Myc, EZH2 and p27 in 129 patients with intermediate-risk prostate cancer were assessed using immunohistochemistry in a semi-quantitative manner. The expression profiles of these three markers were analyzed and investigated for association with biochemical recurrence.Results In all, fifty of 129 cases experienced biochemical recurrence during a median follow-up time of 31 months (range, 6-60 months). Of these relapse patients, one case without and 10 cases with any single positive marker were observed; 39 cases were detected with any two or all three positive markers (22 cases with any two and 17 cases with all three positive markers). Survival analysis showed that patients with over-expression of c-Myc or EZH2, and lower expression of p27 manifested significantly higher biochemical recurrence rates. Subsequent multivariate analysis revealed that c-Myc, EZH2 and p27 expression statuses showed potential in predicting relapse, respectively. Notably, combining three markers together as a "composite index" (0 or 1, vs. 2 or 3 positive markers) provided powerful prognostic value (HR 6.57, 95% Cl 3.02-14.31, P