EFFICACY OF AN AIR-CLEANING DEVICE EQUIPPED WITH A HIGH-EFFICIENCY PARTICULATE AIR FILTER IN HOUSE DUST MITE RESPIRATORY ALLERGY
EFFICACY OF AN AIR-CLEANING DEVICE EQUIPPED WITH A HIGH-EFFICIENCY PARTICULATE AIR FILTER IN HOUSE DUST MITE RESPIRATORY ALLERGY
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DOI：
10.1111/j.1398-9995.1991.tb00629.x
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发表时间：
1991-11-01
期刊：
影响因子：
12.4
通讯作者：
BONIFAZI, F
中科院分区：
文献类型：
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作者：
ANTONICELLI, L;BILO, MB;BONIFAZI, F
在对屋尘螨过敏的患者中研究了配备高效颗粒空气 (HEPA) 过滤器（无需进一步避免措施）的空气清洁设备的功效。空气净化器对室内螨虫的影响。使用交叉对照研究评估了九名螨过敏患者的水平、症状评分和支气管高反应性。对室内螨螨没有显着影响。将空气净化器活动期（2 个月）与对照期（2 个月）进行比较时的水平。螨属 (Dermatophagoides sp.)研究房屋中的水平低于哮喘发作的风险水平，因此很难评估对哮喘的影响；然而，空气净化器活动并未改变支气管高反应性和鼻炎症状评分。然而，在试验期间，Dermatophagoides sp. 的平均水平。房屋中的过敏原自发地从 4.4-mu-g/g（前 2 个月试验的平均水平）变为 1.75-mu-g/g 灰尘（第二个月）（P < 0.05）。由于这一变化，平均鼻炎症状评分也下降了 (P < 0.05)，即使没有证明显着相关性 (r = 0.4 P = 0.089)。 HEPA 过滤器空气净化器似乎不足以替代螨过敏患者的标准避免措施。
The efficacy of an air-cleaning device equipped with a high efficiency particulate air (HEPA) filter (without further avoidance measures) was studied in patients allergic to house dust mite. The effects of the air-cleaner on indoor Dermatophagoides sp. levels, symptom score and bronchial hyperresponsiveness in nine mite-allergic patients were assessed using a cross-over controlled study. No significant effect was demonstrated on indoor Dermatophagoides sp. levels when comparing the period of air-cleaner activity (2 months) with the control period (2 months). The Dermatophagoides sp. levels in the houses studied were lower than the risk level for asthmatic attacks, making it difficult to assess any effect on asthma; however, neither bronchial hyperresponsiveness nor rhinitis symptom score were changed by air-cleaner activity. During the trial period, however the mean level of Dermatophagoides sp. allergen in the houses changed spontaneously from 4.4-mu-g/g (mean level in the first 2 trial months) to 1.75-mu-g/g of dust (second 2 months) (P < 0.05). Owing to this change, the mean rhinitis symptom score also decreased (P < 0.05), even if no significant correlation was demonstrated (r = 0.4 P = 0.089). HEPA filter air-cleaners appear insufficient as substitutes for standard avoidance measures in mite allergic patients.