A broadening world of bacterial small RNAs.

A broadening world of bacterial small RNAs.
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DOI:
10.1016/j.mib.2009.11.004
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发表时间:
2010-02
影响因子:
5.4
通讯作者:
Camilli, Andrew
Camilli, Andrew
中科院分区:
生物学2区
文献类型:
--
作者:
Liu, Jane M.;Camilli, Andrew

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小RNA(sRNA)在细菌中的普遍性现在已经得到了很好的证实。这些转录物是参与从应激适应到毒性到代谢的各种过程的调节回路的成员。最近的大规模搜索表明,即使在最好的细菌转录组研究中,sRNA也比以前预测的要多很多倍。基于这些和其他最近发现的调节sRNAs不以“经典”方式发挥作用,我们建议扩大sRNAs的工作定义。
The ubiquity of small RNAs (sRNAs) in bacteria is now well established. These transcripts are members of regulatory circuits involved in diverse processes ranging from stress adaptation to virulence to metabolism. Recent large-scale searches suggest that there exist many times more sRNAs than previously predicted even in the best studied of bacterial transcriptomes. Based on these and other recent findings of regulatory sRNAs that do not function in a “classical” manner, we propose that the working definition of sRNAs be broadened.
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