p53 status has no prognostic significance in glioblastomas treated with radiotherapy.
p53 status has no prognostic significance in glioblastomas treated with radiotherapy.
复制标题
p53 状态对于接受放射治疗的胶质母细胞瘤没有预后意义。
作者：
J. Baxendine;I. Campbell;D. Ellison
肿瘤抑制基因TP53的突变和p53蛋白的积累是包括胶质母细胞瘤在内的脑星形细胞肿瘤的常见事件，但这些事件是否与预后相关尚不确定。有证据表明，多种肿瘤对放疗的反应可能受p53状态的影响，而p53参与细胞周期和凋亡的控制。本研究验证了p53控制接受放疗的胶质母细胞瘤患者（n = 62）生存率的假设。采用标准方法进行TP53和p53免疫组化分析。27%的肿瘤存在TP53突变，而50%的肿瘤存在p53免疫阳性（LI > 3%）。高p53 LI（> 50%）与突变存在很强的相关性（p < 0.0001），但p53在基因或蛋白质水平上的状态与生存无关。辐射诱导的不依赖于p53的细胞凋亡，以及胶质母细胞瘤中存在的基因异常也参与细胞对辐射的反应，如pRb的缺失和突变，可能是这一结果的解释。
Mutation of the tumor suppressor gene TP53 and accumulation of the p53 protein are common events in the range of cerebral astrocytic tumors, including glioblastomas, but it is uncertain whether these events are associated with prognosis. Evidence suggests that the response of various tumors to radiotherapy may be influenced by the status of p53 which is involved in control of the cell cycle and apoptosis. This study tests the hypothesis that p53 governs survival in patients (n = 62) with glioblastomas who have received radiotherapy. Analysis of TP53 and p53 immunohistochemistry were undertaken using standard methods. TP53 mutations were present in 27% tumors, while 50% were p53-immunopositive (LI > 3%). A strong correlation (p < 0.0001) was found between a high p53 LI (> 50%) and the presence of a mutation, but p53 status at the level of gene or protein was unrelated to survival. Radiation-induced apoptosis that is independent of p53, and the presence in glioblastomas of genetic abnormalities that are also involved in the cellular response to radiation, such as deletions and mutations of pRb, are possible explanations of this result.