REGIONAL CEREBRAL BLOOD-FLOW AND COGNITIVE FUNCTION IN HUNTINGTONS-DISEASE AND SCHIZOPHRENIA - A COMPARISON OF PATIENTS MATCHED FOR PERFORMANCE ON A PREFRONTAL-TYPE TASK
REGIONAL CEREBRAL BLOOD-FLOW AND COGNITIVE FUNCTION IN HUNTINGTONS-DISEASE AND SCHIZOPHRENIA - A COMPARISON OF PATIENTS MATCHED FOR PERFORMANCE ON A PREFRONTAL-TYPE TASK
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DOI：
10.1001/archneur.1990.00530040062020
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发表时间：
1990-04-01
影响因子：
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通讯作者：
WEINBERGER, DR
中科院分区：
文献类型：
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作者：
GOLDBERG, TE;BERMAN, KF;WEINBERGER, DR
匹配患者的病因不同，但临床上重叠的认知障碍的性能的区域特定的神经心理学任务是一种新的和潜在的强大的方法，突出不同的病理生理机制受损的认知。我们使用这种策略来比较亨廷顿病（HD）和精神分裂症（SC）患者，这两种疾病在认知障碍方面有相似之处。根据威斯康星州卡片分类测试“前额叶”功能的表现对患者进行匹配，之后确定神经心理学测试数据和局部脑血流数据，同时检查进行威斯康星州卡片分类测试的患者。HD患者在视觉空间任务和回忆记忆方面的表现比SC患者差，尽管韦氏成人智力量表-修订版IQ和韦氏记忆量表记忆能力相当。这些差异不能归因于索引任务，威斯康星州卡片分类测试的差异。HD和SC患者的局部脑血流表现出双重分离。SC患者额叶血流相对较低，顶叶血流相对较高，而HD患者表现出相反的模式。因此，本研究中的局部脑血流量和神经心理学结果似乎表明，HD和SC中执行功能的单一最终常见认知障碍与两种明显不同的病理生理状态相关。
Matching patients with etiologically distinct but clinically overlapping cognitive disorders on performance of a regionally specific neuropsychological task is a novel and potentially powerful approach to highlighting differences in the pathophysiological mechanisms of impaired cognition. We used this strategy to compare patients with Huntington''s disease (HD) and schizophrenia (SC), disorders that share similarities in cognitive impairment. Patients were matched on the basis of performance on the Wisconsin Card Sorting test of "prefrontal" function, after which neuropsychological test data and regional cerebral blood flow data were determined while patients who performed the Wisconsin Card Sorting test were examined. Patients with HD performed worse on visuospatial tasks and recall memory than did patients with SC, although Wechsler Adult Intelligence Scales-Revised IQ and Wechsler Memory Scale memory quotients were equivalent. These differences could not be attributed to differences on the index task, the Wisconsin Card Sorting Test. Patients with HD and SC exhibited a double dissociation in regional cerebral blood flow. The patients with SC had relatively low frontal and high parietal flows, while patients with HD exhibited the reverse of this pattern. Thus, the regional cerebral blood flow and neuropsychological findings in this study appeared to demonstrate that the single final common cognitive impairment of executive function in HD and SC is associated with two markedly dissimilar pathophysiological states.