Recent progress on sugarcane-bagasse based lactic acid production: Technical advancements, potential and limitations
Recent progress on sugarcane-bagasse based lactic acid production: Technical advancements, potential and limitations
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DOI：
10.1016/j.indcrop.2022.116132
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发表时间：
2023-03
影响因子：
5.9
通讯作者：
Deepti Agrawal;Vinod Kumar
中科院分区：
文献类型：
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作者：
Deepti Agrawal;Vinod Kumar
印度是亚洲最大的甘蔗生产国，其制糖业是第二大农基工业。甘蔗渣（SCB）是制糖工业的主要废弃物，无可争议地是嵌入了超过60%碳水化合物的木质纤维素生物质（LCB），使其成为可发酵糖的可再生来源。尽管SCB具有独特的化学成分，但它主要用于热电联产。利用生物化学的方法来创造糖平台，可以释放出SCB的巨大潜力。糖作为发酵生产几种可再生燃料和化学品的原料，被认为是快速工业化的关键驱动力。美国能源部预测，乳酸（LA）由于其多样化的应用和数十亿美元的市场，将成为顶级生物质衍生平台化学品之一。目前，LA的工业生产主要是通过微生物发酵（约90%）进行的，其主要使用富含淀粉或糖的食用原料。如果其依赖LCB的低成本制造业得以实现，对印度等新兴经济体来说可能是一个布恩，战略性地加强了它们的社会经济地位。本文综述了以SCB为原料，利用生物化学途径实现LA工业化生产的技术进展。它全面讨论了在预处理，糖化和发酵领域开发的策略，弥合实验室规模和工业LA生产之间的差距。它提供了SCB衍生LA的下游加工的一瞥，这仍然处于其新生阶段，并简要地谈论了我们对LA作为“制糖工业”中比其他生物基燃料和化学品更优选的放大选择的观点。
India is the largest producer of sugarcane in Asia and its sugar industry represents the second largest agro-based industry. Sugarcane bagasse (SCB), a major waste from sugar industries, is indisputably lignocellulosic biomass (LCB) embedding ∼60 % carbohydrates, making it a renewable source of fermentable sugars. Despite its unique chemical composition, SCB is primarily used for co-generation. The enormous potential of SCB can be unleashed, if sugar platform is created using biochemical route. Sugars serve as feedstock for fermentative production of several renewable fuels and chemicals, considered as key drivers for rapid industrialization. US Department of Energy has projected lactic acid (LA) as one of the top biomass-derived platform chemicals owing to its diverse applications and multi-billion-dollar market. Currently, the industrial production of LA is predominated by microbial fermentation (∼90 %) which principally uses the starchy or sugar-rich edible feedstocks. If its low-cost manufacturing relying on LCB is enabled, it can be a boon for emerging economies like India, strategically strengthening their socio-economic status. The present review showcases the technical advances made in exploiting the biochemical route towards commercial realization of LA production with SCB as the feedstock. It comprehensively discusses strategies developed in the area of pretreatment, saccharification and fermentation, bridging the gap between lab-scale and industrial LA production. It gives a glimpse on downstream processing of SCB-derived LA, which is still in its nascent stage and briefly talks about our perspective on LA as preferred choice for scale-up in “sugar industry” over other bio-based fuels and chemicals.