Age stability of human brain 5-HT terminals studied with [3H]paroxetine binding.
Age stability of human brain 5-HT terminals studied with [3H]paroxetine binding.
复制标题
通过[3H]帕罗西汀结合研究人脑 5-HT 末端的年龄稳定性。
作者：
A. Andersson;I. Sundman;J. Marcusson
在两组大脑中研究了年龄对[3H]帕罗西汀标记的血清素摄取位点的影响。第一组包括28名年龄在0到100岁之间的受试者（19名男性和9名女性）。研究了扣带回皮层和杏仁核。结合力（Bmax）和结合亲和力（Kd）未见年龄相关的变化。在第二组中，研究了22名年龄在16岁到75岁之间的受试者（18名男性和4名女性）的额叶皮层和下丘脑。未观察到与年龄相关的结合变化。死亡和组织冷冻之间的时间间隔对这种结合没有影响。关于[3H]帕罗西汀结合作为5-HT末端的间接标记物，数据表明人脑中5-HT末端随着年龄的增长而稳定。
The effect of age on serotonin uptake sites labeled with [3H]paroxetine was studied in two sets of brains. The first set included 28 subjects (19 males and 9 females) between the ages 0 and 100 years. The cortex of cingulate gyrus and the amygdala were studied. No age-related changes in binding capacity (Bmax) or binding affinity (Kd) were noted. In the second set, the frontal cortex and hypothalamus from 22 subjects (18 males and 4 females) between 16 and 75 years were studied. No age-related changes in the binding were observed. The interval between death and freezing of the tissue did not influence the binding. Regarding the [3H]paroxetine binding as an indirect marker for 5-HT terminals, the data suggest a stability of 5-HT terminals with increasing age in the human brain.