Apoptosis in peripheral CD4+T cells and thymocytes by Marek's disease virus-infection.

Apoptosis in peripheral CD4+T cells and thymocytes by Marek's disease virus-infection.
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马立克氏病病毒感染导致外周 CD4 T 细胞和胸腺细胞凋亡。

DOI：
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发表时间：
1997
期刊：
Leukemia
影响因子：
11.4
通讯作者：
M. Onuma
M. Onuma
中科院分区：
医学1区
文献类型：
--
作者：
T. Morimura;K. Ohashi;Y. Kon;M. Hattori;C. Sugimoto;M. Onuma

文献摘要

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Histological study revealed that Marek's disease virus (MDV) can cause apoptosis in peripheral blood lymphocytes (PBL) in latently infected chickens. Analysis of DNA fragmentation indicated that CD4+T cells but not CD8+T cells underwent apoptosis. These apoptotic changes were also observed in the thymus during the acute phase of the infection. Flow cytometry analysis showed the drastic decrease of CD4+CD8+ thymocytes, indicating that MDV can induce apoptosis in CD4+CD8+ immature thymocytes in acutely infected chickens. These changes might be involved in the immuno-suppression induced by MDV.