Cholinergic neurons mediate CaMKII-dependent enhancement of courtship suppression
Cholinergic neurons mediate CaMKII-dependent enhancement of courtship suppression
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DOI：
10.1101/lm.317806
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发表时间：
2006-11-01
影响因子：
2
通讯作者：
Griffith, Leslie C.
中科院分区：
文献类型：
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作者：
Mehren, Jennifer E.;Griffith, Leslie C.
在果蝇中，钙/钙调素依赖的蛋白激酶II(CaMKII)的活性在联合求偶条件反射中至关重要，在与交配的雌性动物训练时，这两种条件作用都是形成记忆和抑制求偶。我们之前已经证明，增加一部分神经元中固有的活跃CaMKII的水平，而不是钙依赖的CaMKII，可以降低最初的求偶水平，并增强对交配的雌性的求爱抑制率。在这项研究中，我们证明了非胆碱能、非多巴胺、非GABA能神经元亚群可以导致CaMKII依赖的初始求爱减少，但只有胆碱能神经元增强训练依赖的抑制。这些数据表明，在两个神经元亚群中处理信息素信号，可能是触角叶投射神经元，对行为可塑性至关重要。
In Drosophila, calcium/calmodulin-dependent protein kinase II (CaMKII) activity is crucial in associative courtship conditioning for both memory formation and suppression of courtship during training with a mated female. We have previously shown that increasing levels of constitutively active CaMKII, but not calcium-dependent CaMKII, in a subset of neurons can decrease the initial level of courtship and enhance the rate of suppression of courtship in response to a mated female. In this study, we demonstrate that a subpopulation of noncholinergic, nondopaminergic, non-GABAergic neurons can cause CaMKII-dependent reductions in initial courtship, but only cholinergic neurons enhance training-dependent suppression. These data suggest that processing of pheromonal signals in two subpopulations of neurons, likely antennal lobe projection neurons, is critical for behavioral plasticity.