A NONSPECIFIC INCREASE IN PERMEABILITY IN ESCHERICHIA COLI PRODUCED BY EDTA
A NONSPECIFIC INCREASE IN PERMEABILITY IN ESCHERICHIA COLI PRODUCED BY EDTA
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DOI：
10.1073/pnas.53.4.745
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发表时间：
1965-01-01
影响因子：
11.1
通讯作者：
LEIVE, L
中科院分区：
文献类型：
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作者：
LEIVE, L
大肠杆菌经乙二胺四乙酸(EDTA)处理后，在一定条件下可被几个原本不能被其渗透的无关分子所渗透。这种渗透性的增加解释了这种制剂对抗生素放线菌素的敏感性，放线菌素通常对大肠杆菌无效。尽管通透性屏障受损，这些细胞仍以正常的速度生长。
Escherichia coli, treated with ethylenediamine tetraacetic acid (EDTA), under certain conditions becomes permeable to several unrelated molecules to which it is otherwise impermeable. This increased permeability explains the sensitivity of such preparations to the antibiotic actinomycin, which is normally ineffective against E. coli. Such cells grow at a normal rate despite this impairment of a permeability barrier.