SENSORY NEUROPATHY FROM PYRIDOXINE ABUSE - A NEW MEGAVITAMIN SYNDROME
SENSORY NEUROPATHY FROM PYRIDOXINE ABUSE - A NEW MEGAVITAMIN SYNDROME
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DOI：
10.1056/nejm198308253090801
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发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
BROWN, MJ
中科院分区：
文献类型：
--
作者：
SCHAUMBURG, H;KAPLAN, J;BROWN, MJ
描述了 7 名成年人在每日摄入高水平吡哆醇（维生素 B6）后出现共济失调和严重感觉神经系统功能障碍的情况。其中四人严重残疾；停药后一切都有好转。虚弱并不是这种情况的特征，中枢神经系统在临床上也没有受到影响。尽管食用大剂量吡哆醇已获得公众的广泛接受，但有证据表明它可能导致感觉神经病或神经元病综合征，因此应为使用这种广泛滥用的维生素制定安全指南。
Seven adults who had ataxia and severe sensory-nervous-system dysfunction after daily high-level pyridoxine (vitamin B6) consumption are described. Four were severely disabled; all improved after withdrawal. Weakness was not a feature of this condition, and the CNS was clinically spared. Although consumption of large doses of pyridoxine has gained wide public acceptance, there is evidence that it can cause sensory neuropathy or neuronopathy syndromes and that safe guidelines should be established for the use of this widely abused vitamin.