Quantitative aspiration during sleep in normal subjects
Quantitative aspiration during sleep in normal subjects
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DOI：
10.1378/chest.111.5.1266
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发表时间：
1997-05-01
期刊：
影响因子：
9.6
通讯作者：
Maxwell, SL
中科院分区：
文献类型：
--
作者：
Gleeson, K;Eggli, DF;Maxwell, SL
研究目的：确定受试者内的变异性，并估计正常人睡眠期间鼻咽分泌物的隐匿性吸入量。设计：前瞻性重复整夜睡眠研究。设置：肺睡眠实验室，大学医院。参与者：10名年龄在22至55岁的正常男性志愿者。干预措施：在EEG记录的睡眠期间，通过小导管将2 mL/h放射性Tc-99 m示踪剂输注到鼻咽中进行两次整夜多导睡眠描记。在最终觉醒后立即进行标准肺部扫描。抽吸定义为在两个单独的视图上肺实质中存在放射性。结果：平均睡眠效率为85.7 +/- 2.6%，两个研究夜晚之间没有差异。研究的10例受试者中，共有5例在最终觉醒后肺实质中有明显的示踪剂。3只在第一晚研究后示踪剂明显，4只在第二晚研究后示踪剂明显。因此，两名受试者在两个晚上都吸气。比较吸气和不吸气的受试者，在年龄、卧床时间、睡眠效率、呼吸暂停低通气指数、觉醒加觉醒指数或仰卧位睡眠时间百分比方面没有发现显著差异。示踪剂吸入的数量是在0.01至0.2毫升的数量级。结论：通过这种技术测量的吸入通常发生在健康的年轻男性在睡眠中，是无关的睡眠质量，并在一个以上的场合研究的受试者是可变的。吸出的数量级可能包含生理上显著数量的细菌有机体。
Study objective: To determine the within-subject variability and to estimate the quantity of occult aspiration of nasopharyngeal secretions during sleep in normal humans.Design: Prospective duplicate full-night sleep studies.Setting: Pulmonary sleep laboratory, university hospital.Participants: Ten normal male volunteers aged 22 to 55 years.Interventions: Two full-night polysomnographic recordings with infusion of 2 mL/h radioactive Tc-99m tracer into the nasopharynx through a small catheter during EEG-documented sleep. Standard lung scans were conducted immediately following final awakening. Aspiration was defined as the presence of radioactivity in the pulmonary parenchyma on two separate views. Results: A mean sleep efficiency of 85.7 +/- 2.6% was found with no difference between the two study nights. A total of 5 of the 10 subjects studied had tracer evident in the pulmonary parenchyma following final awakening. Three had the tracer apparent following the first-night study and four had tracer apparent following the second-night study. Thus, two subjects aspirated on both nights. Comparing the subjects who aspirated with those who did not, no significant difference could be found for age, time spent in bed, sleep efficiency, apnea-hypopnea index, arousal plus awakening index, or percent of sleep time spent in a supine position. The quantities of tracer aspirated were on the order of magnitude of 0.01 to 0.2 mL.Conclusions: Aspiration measured by this technique occurs commonly in healthy young men during sleep, is unrelated to sleep quality, and is variable within subjects studied on more than one occasion. The quantity aspirated is of an order of magnitude likely to contain bacterial organisms in physiologically significant quantities.