Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65
Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65
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DOI：
10.1016/j.jclinane.2022.110846
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发表时间：
2022-04-27
影响因子：
6.7
通讯作者：
Bardia, Amit
中科院分区：
文献类型：
--
作者：
Schonberger, Robert B.;Dai, Feng;Bardia, Amit
研究目的：我们的目的是研究丙泊酚诱导剂量（mg/kg）与切口前严重低血压的关系在年龄>65岁的患者中（平均动脉压（MAP）< 55 mmHg）。设计：回顾性观察。设置：参与多中心围手术期结局组联盟的40个中心。患者：2014年1月至2018年12月期间，接受非心脏、非血管手术并在气管插管前接受丙泊酚全身麻醉诱导的>65岁患者。干预措施：测量：主要暴露量为丙泊酚诱导总剂量（mg/kg），主要结局为严重低血压（MAP）的发生
Study objective: We aimed to study the association between propofol induction dose (mg/kg) and pre-incision severe hypotension (Mean Arterial Pressure (MAP) < 55 mmHg) among patients >65 years of age.Design: Retrospective Observational.Setting: 40 centers participating in the Multicenter Perioperative Outcomes Group consortium.Patients: Patients >65 years of age undergoing non-cardiac, non-vascular surgery who received propofol for general anesthetic induction prior to endotracheal intubation between January 2014 and December 2018.Interventions: None.Measurements: The primary exposure was total propofol induction dose in mg/kg, and the primary outcome was occurrence of severe hypotension (MAP