Dissecting Sholl Analysis into Its Functional Components
Dissecting Sholl Analysis into Its Functional Components
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DOI：
10.1016/j.celrep.2019.04.097
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发表时间：
2019-06-04
期刊：
影响因子：
8.8
通讯作者：
Cuntz, Hermann
中科院分区：
文献类型：
--
作者：
Bird, Alex D.;Cuntz, Hermann
60多年来，Sholl分析一直是树突解剖学中的一项重要技术。Sholl相交轮廓是通过对距离体体给定距离的树突分支的数量进行计数而获得的，是树突复杂性的关键度量；它的应用范围从评估病理引起的结构变化到估计预期的解剖突触接触数量。我们发现，大多数神经元的Sholl相交轮廓可以通过三个基本的功能度量来重现：树突所跨越的区域，树突的总长度，以及树突段偏离到胞体的直接路径的角度分布(即根角分布)。前两个指标由轴突位置决定，因此由微电路结构决定；第三个指标来自最优连接，代表了估计神经元传导速度需求的分支统计量。
Sholl analysis has been an important technique in dendritic anatomy for more than 60 years. The Sholl intersection profile is obtained by counting the number of dendritic branches at a given distance from the soma and is a key measure of dendritic complexity; it has applications from evaluating the changes in structure induced by pathologies to estimating the expected number of anatomical synaptic contacts. We find that the Sholl intersection profiles of most neurons can be reproduced from three basic, functional measures: the domain spanned by the dendritic arbor, the total length of the dendrite, and the angular distribution of how far dendritic segments deviate from a direct path to the soma (i.e., the root angle distribution). The first two measures are determined by axon location and hence microcircuit structure; the third arises from optimal wiring and represents a branching statistic estimating the need for conduction speed in a neuron.