The role of fluoroquinolones in the promotion of alginate synthesis and antibiotic resistance in Pseudomonas aeruginosa.
The role of fluoroquinolones in the promotion of alginate synthesis and antibiotic resistance in Pseudomonas aeruginosa.
复制标题
氟喹诺酮类药物在促进铜绿假单胞菌藻酸盐合成和抗生素耐药性中的作用。
DOI：
10.1007/s002849900220
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发表时间：
1997
影响因子：
2.6
通讯作者：
Mattingly,SJ
中科院分区：
文献类型：
--
作者：
Piña,SE;Mattingly,SJ
使用靶向拓扑异构酶 II A 亚基的旋转酶抑制剂（例如环丙沙星、诺氟沙星和氧氟沙星）治疗非粘液铜绿假单胞菌，导致 100% 转化为粘液表型。然而，在葡萄糖酸限制的恒化器培养系统中，部分抑制非粘液分离株的生长和大分子合成（DNA、RNA、蛋白质或肽聚糖）的抗生素并不能促进向粘液亚群的转化。在表达粘液表型的群体中观察到抵抗力增加。当撤掉环丙沙星压力时，粘液转化和抗生素耐药性都是完全可逆的，但通过去除诺氟沙星和氧氟沙星只能部分可逆。因此，这些实验表明，在一些氟喹诺酮类药物存在的情况下，可能会发生导致粘液转化和抗生素耐药性的条件反应。
Treatment of nonmucoidPseudomonas aeruginosawith gyrase inhibitors such as ciprofloxacin, norfloxacin, and ofloxacin, which target the A subunit of topoisomerase II, resulted in 100% conversion to the mucoid phenotype. However, antibiotics that partially inhibited growth and macromolecular synthesis (DNA, RNA, protein, or peptidoglycan) of nonmucoid isolates in a gluconate-limited chemostat culture system did not promote conversion to mucoid subpopulations. An increase in resistance was observed in populations that expressed the mucoid phenotype. Both mucoid conversion and antibiotic resistance were completely reversible when ciprofloxacin pressure was withdrawn, but only partially reversible by the removal of norfloxacin and ofloxacin. Thus, these experiments indicate that in the presence of some fluoroquinolones, a conditional response resulting in mucoid conversion and antibiotic resistance may occur.